DHH1/YDL160C Protein Information Help

Standard Name Dhh1p 1
Systematic Name Ydl160cp
ORF Classification Verified
Description Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress (2, 3, 4, 5, 6)
Name Description DEAD box Helicase Homolog 1
Experimental Data
Molecules/cell 42900 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 506
Molecular Weight (Da) 57,544
Isoelectric Point (pI) 7.97

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Dhh1p (InterPro)
Physical Interactions There are 423 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052F27 | P39517
MIPS: YDL160C
NCBI: 1061279 | 1431254 | 4353 | 61679843 | 6320041 | 729329 | NP_010121.1
GenBank/EMBL/DDBJ: DAA11700.1 | X66057 | Z67750 | Z74208
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
Amino Acid Sequence (or in FASTA format)
 
       1  MGSINNNFNT NNNSNTDLDR DWKTALNIPK KDTRPQTDDV LNTKGNTFED
      51  FYLKRELLMG IFEAGFEKPS PIQEEAIPVA ITGRDILARA KNGTGKTAAF
     101  VIPTLEKVKP KLNKIQALIM VPTRELALQT SQVVRTLGKH CGISCMVTTG
     151  GTNLRDDILR LNETVHILVG TPGRVLDLAS RKVADLSDCS LFIMDEADKM
     201  LSRDFKTIIE QILSFLPPTH QSLLFSATFP LTVKEFMVKH LHKPYEINLM
     251  EELTLKGITQ YYAFVEERQK LHCLNTLFSK LQINQAIIFC NSTNRVELLA
     301  KKITDLGYSC YYSHARMKQQ ERNKVFHEFR QGKVRTLVCS DLLTRGIDIQ
     351  AVNVVINFDF PKTAETYLHR IGRSGRFGHL GLAINLINWN DRFNLYKIEQ
     401  ELGTEIAAIP ATIDKSLYVA ENDETVPVPF PIEQQSYHQQ AIPQQQLPSQ
     451  QQFAIPPQQH HPQFMVPPSH QQQQAYPPPQ MPSQQGYPPQ QEHFMAMPPG
     501  QSQPQY*

external links for Dhh1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Dhh1p
1) Strahl-Bolsinger S and Tanner W  (1993) A yeast gene encoding a putative RNA helicase of the "DEAD"-box family. Yeast 9(4):429-32
2) Coller JM, et al.  (2001) The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes. RNA 7(12):1717-27
3) Tseng-Rogenski SS, et al.  (2003) Functional conservation of Dhh1p, a cytoplasmic DExD/H-box protein present in large complexes. Nucleic Acids Res 31(17):4995-5002
4) Bergkessel M and Reese JC  (2004) An essential role for the Saccharomyces cerevisiae DEAD-box helicase DHH1 in G1/S DNA-damage checkpoint recovery. Genetics 167(1):21-33
5) Chang LC and Lee FJ  (2012) The RNA helicase Dhh1p cooperates with Rbp1p to promote porin mRNA decay via its non-conserved C-terminal domain. Nucleic Acids Res 40(3):1331-44
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41