MSH5/YDL154W Protein Information Help

Standard Name Msh5p 1
Systematic Name Ydl154wp
ORF Classification Verified
Description Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans (2, 3, 4)
Name Description MutS Homolog 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 901
Molecular Weight (Da) 102,208
Isoelectric Point (pI) 4.98

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Msh5p (InterPro)
Physical Interactions There are 10 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012F5F8 | Q12175
MIPS: YDL154W
NCBI: 1321950 | 1431243 | 2497997 | 6320047 | 836681 | NP_010127.1
GenBank/EMBL/DDBJ: DAA11706.1 | L42517 | X97751 | Z74202
Amino Acid Sequence (or in FASTA format)
 
       1  MSHEWLISAS ETMRSIGNGE GLRDKGAVVA NNDGEFNEGD TNREEDSSTI
      51  FSFDFDEEIV MCIDFSGGKL GCSILDYHTK TLKAFDQDYV VNKTTISSHD
     101  LIDDADMSSN DISLLLGLLI MEANPTVCLV PARLEDWIFD YIKTKCDEIN
     151  CRLELQPIKR FKKWDLLQSL QLRGHDNQTI LNDILSNSKF TTTVTLGTVG
     201  CILANHEQLG EYNDSTASSN MVTGRLVQNA FEDVIHGIRY IDIRDRMVLD
     251  ENTISALHIF PTAHKLGHDK MMRNGFFSVF ELFNQVSSDY ARRILKSWLI
     301  NPLTNKKRIE TRYSIIRTLL DKQNAIIFSD LSQSIKRCPD AFGFINQLRS
     351  GKSTLGTWSK VASFLEKGIA IFQLVSSLKL GSDEANILHD IKNKVDISAL
     401  KECLRKVETV IDFDTSRDTK TLTINTGVDN RLDECRNIYN HLEGILLDVA
     451  RETQIFLLNT MPQEDCKTTK SLEKLVNAVY IPQLGYLVTI SVLMEPLLDG
     501  IPNLQWEEIF RSSENIYFKN GRVLELDETY GDIYGAISDF EIEILFSLQE
     551  QILRRKTQLT AYNILLSELE ILLSFAQVSA ERNYAEPQLV EDECILEIIN
     601  GRHALYETFL DNYIPNSTMI DGGLFSELSW CEQNKGRIIV VTGANASGKS
     651  VYLTQNGLIV YLAQIGCFVP AERARIGIAD KILTRIRTQE TVYKTQSSFL
     701  LDSQQMAKSL SLATEKSLIL IDEYGKGTDI LDGPSLFGSI MLNMSKSEKC
     751  PRIIACTHFH ELFNENVLTE NIKGIKHYCT DILISQKYNL LETAHVGEDH
     801  ESEGITFLFK VKEGISKQSF GIYCAKVCGL SRDIVERAEE LSRMINRGDD
     851  VVQQCGNLTE KEMREFQKNQ EIVKKFLSWD LDLETTTTSE NLRLKLKNFL
     901  R*

external links for Msh5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Msh5p
1) Hollingsworth NM, et al.  (1995) MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair. Genes Dev 9(14):1728-39
2) Winand NJ, et al.  (1998) Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene. Genomics 53(1):69-80
3) Pochart P, et al.  (1997) Conserved properties between functionally distinct MutS homologs in yeast. J Biol Chem 272(48):30345-9
4) Bawa S and Xiao W  (2003) A single amino acid substitution in MSH5 results in DNA alkylation tolerance. Gene 315:177-82