ATG9/YDL149W Protein Information Help

Standard Name Atg9p 1
Systematic Name Ydl149wp
Alias Aut9p 2 , Cvt7p 3, 4 , Apg9p 4, 5 , Cvt6p 6
ORF Classification Verified
Description Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS (5, 7, 8, 9)
Name Description AuTophaGy related 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 997
Molecular Weight (Da) 115,402
Isoelectric Point (pI) 5.86

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Atg9p (InterPro)
Transmembrane Domains There are 6 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 52 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053149 | Q12142
MIPS: YDL149W
NCBI: 1321955 | 1431235 | 61211369 | 6320052 | NP_010132.1 | NM_001180209.1
GenBank/EMBL/DDBJ: CAA66342.1 | CAA98723.1 | DAA11709.1 | X97751 | Z74197
Amino Acid Sequence (or in FASTA format)
       1  MERDEYQLPN SHGKNTFLSR IFGLQSDEVN PSLNSQEMSN FPLPDIERGS
      51  SLLHSTNDSR EDVDENDLRV PESDQGTSTE EEDEVDEEQV QAYAPQISDG
     101  LDGDHQLNSV TSKENVLETE KSNLERLVEG STDDSVPKVG QLSSEEEEDN
     151  EFINNDGFDD DTPLFQKSKI HEFSSKKSNT IEDGKRPLFF RHILQNNRPQ
     201  RDTQKLFTSS NAIHHDKDKS ANNGPRNING NQKHGTKYFG SATQPRFTGS
     251  PLNNTNRFTK LFPLRKPNLL SNISVLNNTP EDRINTLSVK ERALWKWANV
     301  ENLDIFLQDV YNYYLGNGFY CIILEKILNI CTLLFVVFVS TYMGHCVDYS
     351  KLPTSHRVSD IIIDKCYSNS ITGFTKFFLW MFYFFVILKI VQLYFDVQKL
     401  SELQNFYKYL LNISDDELQT LPWQNVIQQL MYLKDQNAMT ANVVEVKAKN
     451  RIDAHDVANR IMRRENYLIA LYNSDILNLS LPIPLFRTNV LTKTLEWNIN
     501  LCVMGFVFNE SGFIKQSILK PSQREFTREE LQKRFMLAGF LNIILAPFLV
     551  TYFVLLYFFR YFNEYKTSPG SIGARQYTPI AEWKFREYNE LYHIFKKRIS
     601  LSTTLANKYV DQFPKEKTNL FLKFVSFICG SFVAILAFLT VFDPENFLNF
     651  EITSDRSVIF YITILGAIWS VSRNTITQEY HVFDPEETLK ELYEYTHYLP
     701  KEWEGRYHKE EIKLEFCKLY NLRIVILLRE LTSLMITPFV LWFSLPSSAG
     751  RIVDFFRENS EYVDGLGYVC KYAMFNMKNI DGEDTHSMDE DSLTKKIAVN
     801  GSHTLNSKRR SKFTAEDHSD KDLANNKMLQ SYVYFMDDYS NSENLTGKYQ
     851  LPAKKGYPNN EGDSFLNNKY SWRKQFQPGQ KPELFRIGKH ALGPGHNISP
     901  AIYSTRNPGK NWDNNNNGDD IKNGTNNATA KNDDNNGNND HEYVLTESFL
     951  DSGAFPNHDV IDHNKMLNSN YNGNGILNKG GVLGLVKEYY KKSDVGR*  

external links for Atg9p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) CYC2008 (complexes) MIPS
YGOB Complexome Pfam domains
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Atg9p
1) Klionsky DJ, et al.  (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5(4):539-45
2) Lang T, et al.  (2000) Autophagy and the cvt pathway both depend on AUT9. J Bacteriol 182(8):2125-33
3) Harding TM, et al.  (1995) Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway. J Cell Biol 131(3):591-602
4) Kim, J. et al.  (1998) CVT7 and APG9 are allelic
5) Tsukada M and Ohsumi Y  (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74
6) Lynch-Day MA and Klionsky DJ  (2010) The Cvt pathway as a model for selective autophagy. FEBS Lett 584(7):1359-66
7) Noda T, et al.  (2000) Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways. J Cell Biol 148(3):465-80
8) Reggiori F, et al.  (2004) The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev Cell 6(1):79-90
9) Legakis JE, et al.  (2007) A cycling protein complex required for selective autophagy. Autophagy 3(5):422-32