RGT2/YDL138W Protein Information Help

Standard Name Rgt2p 1
Systematic Name Ydl138wp
ORF Classification Verified
Description Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication (1, 2, 3)
Name Description Restores Glucose Transport 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 763
Molecular Weight (Da) 83,159
Isoelectric Point (pI) 5.95

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rgt2p (InterPro)
Transmembrane Domains There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 5 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013383D | Q12300
MIPS: YDL138W
NCBI: 1419223 | 1431213 | 2500936 | 6320063 | NP_010143.1
GenBank/EMBL/DDBJ: DAA11720.1 | X96876 | Z74186
External Classifications TC: 2.A.1.1 [The Sugar Porter (SP) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MNDSQNCLRQ REENSHLNPG NDFGHHQGAE CTINHNNMPH RNAYTESTND
      51  TEAKSIVMCD DPNAYQISYT NNEPAGDGAI ETTSILLSQP LPLRSNVMSV
     101  LVGIFVAVGG FLFGYDTGLI NSITDMPYVK TYIAPNHSYF TTSQIAILVS
     151  FLSLGTFFGA LIAPYISDSY GRKPTIMFST AVIFSIGNSL QVASGGLVLL
     201  IVGRVISGIG IGIISAVVPL YQAEAAQKNL RGAIISSYQW AITIGLLVSS
     251  AVSQGTHSKN GPSSYRIPIG LQYVWSSILA VGMIFLPESP RYYVLKDELN
     301  KAAKSLSFLR GLPIEDPRLL EELVEIKATY DYEASFGPST LLDCFKTSEN
     351  RPKQILRIFT GIAIQAFQQA SGINFIFYYG VNFFNNTGVD NSYLVSFISY
     401  AVNVAFSIPG MYLVDRIGRR PVLLAGGVIM AIANLVIAIV GVSEGKTVVA
     451  SKIMIAFICL FIAAFSATWG GVVWVVSAEL YPLGVRSKCT AICAAANWLV
     501  NFTCALITPY IVDVGSHTSS MGPKIFFIWG GLNVVAVIVV YFAVYETRGL
     551  TLEEIDELFR KAPNSVISSK WNKKIRKRCL AFPISQQIEM KTNIKNAGKL
     601  DNNNSPIVQD DSHNIIDVDG FLENQIQSND HMIAADKGSG SLVNIIDTAP
     651  LTSTEFKPVE HPPVNYVDLG NGLGLNTYNR GPPSIISDST DEFYEENDSS
     701  YYNNNTERNG ANSVNTYMAQ LINSSSTTSN DTSFSPSHNS NARTSSNWTS
     751  DLASKHSQYT SPQ*

external links for Rgt2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains

Complexome TCDB

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rgt2p
1) Ozcan S, et al.  (1996) Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc Natl Acad Sci U S A 93(22):12428-32
2) Ozcan S, et al.  (1998) Glucose sensing and signaling by two glucose receptors in the yeast Saccharomyces cerevisiae. EMBO J 17(9):2566-73
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Marshall-Carlson L, et al.  (1991) Dominant and recessive suppressors that restore glucose transport in a yeast snf3 mutant. Genetics 128(3):505-12