LYS21/YDL131W Protein Information

Standard Name	Lys21p
Systematic Name	Ydl131wp
ORF Classification	Verified
Description	Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication (1, 2)
Name Description	LYSine requiring

Experimental Data
Molecules/cell	21900 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	440
Molecular Weight (Da)	48,594
Isoelectric Point (pI)	6.25

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Lys21p (InterPro)
Physical Interactions	There are 29 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012CAE6 \| Q12122 MIPS: YDL131W NCBI: 1419231 \| 1431199 \| 2492788 \| 51013333 \| 6320071 \| NP_010151.1 GenBank/EMBL/DDBJ: DAA11728.1 \| AY692941 \| X96876 \| Z74179
External Classifications	EC: 2.3.3.14 [Homocitrate synthase]

Amino Acid Sequence (or in FASTA format)
1 MSENNEFQSV TESTTAPTTS NPYGPNPADY LSNVKNFQLI DSTLREGEQF 51 ANAFFDTEKK IEIARALDDF GVDYIELTSP VASEQSRKDC EAICKLGLKA 101 KILTHIRCHM DDARVAVETG VDGVDVVIGT SKFLRQYSHG KDMNYIAKSA 151 VEVIEFVKSK GIEIRFSSED SFRSDLVDLL NIYKTVDKIG VNRVGIADTV 201 GCANPRQVYE LIRTLKSVVS CDIECHFHND TGCAIANAYT ALEGGARLID 251 VSVLGIGERN GITPLGGLMA RMIVAAPDYV RSKYKLHKIR DIENLVADAV 301 EVNIPFNNPI TGFCAFTHKA GIHAKAILAN PSTYEILDPH DFGMKRYIHF 351 ANRLTGWNAI KSRVDQLNLN LTDDQIKEVT AKIKKLGDVR PLNIDDVDSI 401 IKDFHAELST PLLKPVNKGT DDDNIDISNG HVSKKAKVTK *

Amino Acid Sequence (or in FASTA format)

       1  MSENNEFQSV TESTTAPTTS NPYGPNPADY LSNVKNFQLI DSTLREGEQF
      51  ANAFFDTEKK IEIARALDDF GVDYIELTSP VASEQSRKDC EAICKLGLKA
     101  KILTHIRCHM DDARVAVETG VDGVDVVIGT SKFLRQYSHG KDMNYIAKSA
     151  VEVIEFVKSK GIEIRFSSED SFRSDLVDLL NIYKTVDKIG VNRVGIADTV
     201  GCANPRQVYE LIRTLKSVVS CDIECHFHND TGCAIANAYT ALEGGARLID
     251  VSVLGIGERN GITPLGGLMA RMIVAAPDYV RSKYKLHKIR DIENLVADAV
     301  EVNIPFNNPI TGFCAFTHKA GIHAKAILAN PSTYEILDPH DFGMKRYIHF
     351  ANRLTGWNAI KSRVDQLNLN LTDDQIKEVT AKIKKLGDVR PLNIDDVDSI
     401  IKDFHAELST PLLKPVNKGT DDDNIDISNG HVSKKAKVTK *

external links for Lys21p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Lys21p

1)	Ramos F, et al. (1996) Identification of a gene encoding a homocitrate synthase isoenzyme of Saccharomyces cerevisiae. Yeast 12(13):1315-20
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41