KIN28/YDL108W Protein Information

Standard Name	Kin28p 1
Systematic Name	Ydl108wp
ORF Classification	Verified
Description	Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters (2, 3)
Name Description	protein KINase

Experimental Data
Molecules/cell	4400 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	306
Molecular Weight (Da)	35,247
Isoelectric Point (pI)	6.87

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Kin28p (InterPro)
Physical Interactions	There are 85 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053108 \| P06242 MIPS: YDL108W NCBI: 1199540 \| 125399 \| 1431154 \| 3849 \| 6320095 \| NP_010175.1 GenBank/EMBL/DDBJ: DAA11752.1 \| X04423 \| X95644 \| Z74156
External Classifications	EC: 2.7.11.1 [Non-specific serine/threonine protein kinase] EC: 2.7.11.23 [[RNA-polymerase]-subunit kinase]

Amino Acid Sequence (or in FASTA format)
1 MKVNMEYTKE KKVGEGTYAV VYLGCQHSTG RKIAIKEIKT SEFKDGLDMS 51 AIREVKYLQE MQHPNVIELI DIFMAYDNLN LVLEFLPTDL EVVIKDKSIL 101 FTPADIKAWM LMTLRGVYHC HRNFILHRDL KPNNLLFSPD GQIKVADFGL 151 ARAIPAPHEI LTSNVVTRWY RAPELLFGAK HYTSAIDIWS VGVIFAELML 201 RIPYLPGQND VDQMEVTFRA LGTPTDRDWP EVSSFMTYNK LQIYPPPSRD 251 ELRKRFIAAS EYALDFMCGM LTMNPQKRWT AVQCLESDYF KELPPPSDPS 301 SIKIRN*

Amino Acid Sequence (or in FASTA format)

       1  MKVNMEYTKE KKVGEGTYAV VYLGCQHSTG RKIAIKEIKT SEFKDGLDMS
      51  AIREVKYLQE MQHPNVIELI DIFMAYDNLN LVLEFLPTDL EVVIKDKSIL
     101  FTPADIKAWM LMTLRGVYHC HRNFILHRDL KPNNLLFSPD GQIKVADFGL
     151  ARAIPAPHEI LTSNVVTRWY RAPELLFGAK HYTSAIDIWS VGVIFAELML
     201  RIPYLPGQND VDQMEVTFRA LGTPTDRDWP EVSSFMTYNK LQIYPPPSRD
     251  ELRKRFIAAS EYALDFMCGM LTMNPQKRWT AVQCLESDYF KELPPPSDPS
     301  SIKIRN*

external links for Kin28p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Kin28p

1)	Simon M, et al. (1986) KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28. EMBO J 5(10):2697-701
2)	Rodriguez CR, et al. (2000) Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II. Mol Cell Biol 20(1):104-12
3)	Keogh MC, et al. (2002) Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation. Mol Cell Biol 22(5):1288-97
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41