UBX3/YDL091C Protein Information

Standard Name	Ubx3p 1
Systematic Name	Ydl091cp
ORF Classification	Verified
Description	Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10 (1, 2, 3)
Name Description	UBiquitin regulatory X 1

Experimental Data
Molecules/cell	233 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	455
Molecular Weight (Da)	52,943
Isoelectric Point (pI)	6.32

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ubx3p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B3BF \| Q12229 MIPS: YDL091C NCBI: 1199556 \| 1431122 \| 6320112 \| 77416596 \| NP_010192.1 GenBank/EMBL/DDBJ: DAA11767.1 \| X95644 \| Z74139

Amino Acid Sequence (or in FASTA format)
1 MDIFRHTFGN NDDSFIRIPG AFREEPPADL NGRTEDQNSN TNEPTQSRDG 51 RLKSILHFLF QAPLIVLYYL LNFIVRSSRL LKPLLRLHGF YQRKHNRLLD 101 HSSQLHRLLE NLENEAQAVT CSEGNGNNDD GSNTDSTSNN ESSGVQFSFG 151 SLYNPENGTF SKSIMQNSYT ELLDACSEQV KFGVIYLHDP LLDNHMDYVN 201 KILCSEAFVN MIRKYQVLLW YGDVTTSEGL QVSNALKIRQ YPLLGIISLK 251 AEKKIELIAR VEGSISNYKA QDLEAIFSKN YSRLIQLRQQ RQNIEMQRLI 301 RQQQDSRYQD SLRRDQQRES ERLEQTQREQ MEREHQRIEN QWLLWRKSQL 351 KPEPSSDKDA SKVAIRLENG QRLVRKFDAS LPTEEIYAFV ELQLHDMLNS 401 ENDTLPVYQP ANYQHQYSFK LITPVPRREL DLSTKISDVS GIYPSGNIVM 451 ERLDE*

Amino Acid Sequence (or in FASTA format)

       1  MDIFRHTFGN NDDSFIRIPG AFREEPPADL NGRTEDQNSN TNEPTQSRDG
      51  RLKSILHFLF QAPLIVLYYL LNFIVRSSRL LKPLLRLHGF YQRKHNRLLD
     101  HSSQLHRLLE NLENEAQAVT CSEGNGNNDD GSNTDSTSNN ESSGVQFSFG
     151  SLYNPENGTF SKSIMQNSYT ELLDACSEQV KFGVIYLHDP LLDNHMDYVN
     201  KILCSEAFVN MIRKYQVLLW YGDVTTSEGL QVSNALKIRQ YPLLGIISLK
     251  AEKKIELIAR VEGSISNYKA QDLEAIFSKN YSRLIQLRQQ RQNIEMQRLI
     301  RQQQDSRYQD SLRRDQQRES ERLEQTQREQ MEREHQRIEN QWLLWRKSQL
     351  KPEPSSDKDA SKVAIRLENG QRLVRKFDAS LPTEEIYAFV ELQLHDMLNS
     401  ENDTLPVYQP ANYQHQYSFK LITPVPRREL DLSTKISDVS GIYPSGNIVM
     451  ERLDE*

external links for Ubx3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ubx3p

1)	Schuberth C, et al. (2004) Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. EMBO Rep 5(8):818-24
2)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3)	Ryan CJ, et al. (2012) Hierarchical Modularity and the Evolution of Genetic Interactomes across Species. Mol Cell 46(5):691-704
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41