CBS1/YDL069C Protein Information

Standard Name	Cbs1p
Systematic Name	Ydl069cp
ORF Classification	Verified
Description	Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader (1, 2, 3)
Name Description	Cytochrome B Synthesis 4

Experimental Data
Molecules/cell	556 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	229
Molecular Weight (Da)	26,586
Isoelectric Point (pI)	10.75

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cbs1p (InterPro)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001D476F \| P14066 MIPS: YDL069C NCBI: 1431078 \| 3464 \| 3467 \| 37362630 \| 85683251 \| NP_010214.2 GenBank/EMBL/DDBJ: DAA11789.1 \| X15650 \| X16120 \| Z74117

Amino Acid Sequence (or in FASTA format)
1 MLRTKVFATT VARISGIRRY IPIRTINTVT KKNISKIEKL CEVLEVNPDG 51 YKGKERIPTK ELTKLLYTTS RNMLVRVPMT GDLSTGNTFE TRNETLQKLG 101 EQLIHLEINK MLTITFTNFN QFNIMNKNFN YIHNLDRARV VNMDSISWLI 151 KNSLKINQLA HLRIPANLPK EMGLTSSSND FQNLNDWKVI LSFIGYLKLL 201 EIKNDNKKFI ESIIKTICIP LINYHLRKS*

Amino Acid Sequence (or in FASTA format)

       1  MLRTKVFATT VARISGIRRY IPIRTINTVT KKNISKIEKL CEVLEVNPDG
      51  YKGKERIPTK ELTKLLYTTS RNMLVRVPMT GDLSTGNTFE TRNETLQKLG
     101  EQLIHLEINK MLTITFTNFN QFNIMNKNFN YIHNLDRARV VNMDSISWLI
     151  KNSLKINQLA HLRIPANLPK EMGLTSSSND FQNLNDWKVI LSFIGYLKLL
     201  EIKNDNKKFI ESIIKTICIP LINYHLRKS*

external links for Cbs1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	GeneMANIA

References cited on this page View Complete Literature Guide for Cbs1p

1)	Michaelis U, et al. (1991) Association of cytochrome b translational activator proteins with the mitochondrial membrane: implications for cytochrome b expression in yeast. Mol Gen Genet 230(1-2):177-85
2)	Rodel G and Fox TD (1987) The yeast nuclear gene CBS1 is required for translation of mitochondrial mRNAs bearing the cob 5' untranslated leader. Mol Gen Genet 206(1):45-50
3)	Krause-Buchholz U, et al. (2005) Saccharomyces cerevisiae translational activator Cbs1p is associated with translationally active mitochondrial ribosomes. Biol Chem 386(5):407-15
4)	Rodel G (1986) Two yeast nuclear genes, CBS1 and CBS2, are required for translation of mitochondrial transcripts bearing the 5'-untranslated COB leader. Curr Genet 11(1):41-5
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41