IDP1/YDL066W Protein Information

Standard Name	Idp1p
Systematic Name	Ydl066wp
ORF Classification	Verified
Description	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes (1, 2)
Name Description	Isocitrate Dehydrogenase, NADP-specific

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	428
Molecular Weight (Da)	48,190
Isoelectric Point (pI)	9.45

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Idp1p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 22 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012D1C8 \| P21954 MIPS: YDL066W NCBI: 124160 \| 1431074 \| 171749 \| 193506511 \| 193506512 \| 193506513 \| 193506514 \| 193506515 \| 193506516 \| 193506517 \| 193506518 \| 193506519 \| 193506520 \| 193506521 \| 193506522 \| 193506523 \| 193506524 \| 193506525 \| 193506526 \| 193506527 \| 193506528 \| 193506529 \| 193506530 \| 193506531 \| 193506532 \| 6320137 \| NP_010217.1 GenBank/EMBL/DDBJ: DAA11791.1 \| M57229 \| Z74114
External Classifications	EC: 1.1.1.42 [Isocitrate dehydrogenase (NADP(+))]

Amino Acid Sequence (or in FASTA format)
1 MSMLSRRLFS TSRLAAFSKI KVKQPVVELD GDEMTRIIWD KIKKKLILPY 51 LDVDLKYYDL SVESRDATSD KITQDAAEAI KKYGVGIKCA TITPDEARVK 101 EFNLHKMWKS PNGTIRNILG GTVFREPIVI PRIPRLVPRW EKPIIIGRHA 151 HGDQYKATDT LIPGPGSLEL VYKPSDPTTA QPQTLKVYDY KGSGVAMAMY 201 NTDESIEGFA HSSFKLAIDK KLNLFLSTKN TILKKYDGRF KDIFQEVYEA 251 QYKSKFEQLG IHYEHRLIDD MVAQMIKSKG GFIMALKNYD GDVQSDIVAQ 301 GFGSLGLMTS ILVTPDGKTF ESEAAHGTVT RHYRKYQKGE ETSTNSIASI 351 FAWSRGLLKR GELDNTPALC KFANILESAT LNTVQQDGIM TKDLALACGN 401 NERSAYVTTE EFLDAVEKRL QKEIKSIE*

Amino Acid Sequence (or in FASTA format)

       1  MSMLSRRLFS TSRLAAFSKI KVKQPVVELD GDEMTRIIWD KIKKKLILPY
      51  LDVDLKYYDL SVESRDATSD KITQDAAEAI KKYGVGIKCA TITPDEARVK
     101  EFNLHKMWKS PNGTIRNILG GTVFREPIVI PRIPRLVPRW EKPIIIGRHA
     151  HGDQYKATDT LIPGPGSLEL VYKPSDPTTA QPQTLKVYDY KGSGVAMAMY
     201  NTDESIEGFA HSSFKLAIDK KLNLFLSTKN TILKKYDGRF KDIFQEVYEA
     251  QYKSKFEQLG IHYEHRLIDD MVAQMIKSKG GFIMALKNYD GDVQSDIVAQ
     301  GFGSLGLMTS ILVTPDGKTF ESEAAHGTVT RHYRKYQKGE ETSTNSIASI
     351  FAWSRGLLKR GELDNTPALC KFANILESAT LNTVQQDGIM TKDLALACGN
     401  NERSAYVTTE EFLDAVEKRL QKEIKSIE*

external links for Idp1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Idp1p

1)	Haselbeck RJ and McAlister-Henn L (1991) Isolation, nucleotide sequence, and disruption of the Saccharomyces cerevisiae gene encoding mitochondrial NADP(H)-specific isocitrate dehydrogenase. J Biol Chem 266(4):2339-45
2)	Haselbeck RJ and McAlister-Henn L (1993) Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases. J Biol Chem 268(16):12116-22