SYO1/YDL063C Protein Information

Standard Name	Syo1p 1
Systematic Name	Ydl063cp
ORF Classification	Verified
Description	Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus (1, 2, 3, 4)
Name Description	SYnchronized impOrt or SYmpOrtin 1

Experimental Data
Molecules/cell	2600 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	620
Molecular Weight (Da)	70,164
Isoelectric Point (pI)	4.93

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Syo1p (InterPro)
Physical Interactions	There are 10 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000069FC7 \| Q07395 MIPS: YDL063C NCBI: 1431067 \| 1903281 \| 6320141 \| 74583632 \| NP_010220.1 GenBank/EMBL/DDBJ: DAA11794.1 \| Z74109 \| Z74111

Amino Acid Sequence (or in FASTA format)
1 MGRSKKRSRA SSSRLNPLRK AGSNDNNKDT NVVNKKLQPL LQNLSSVVPN 51 DRSIALSSIS VLCEDAHMRQ LLLKEKLVPI ILNKLLNDSN SDIVVESFGL 101 LRNLSLEEGY DVSIYLWRSD IWTSITSNFG RIVESLSALQ AAEQQPQLKP 151 AGKSKIESKR LLFDFADNLL SLVVALSNGS DDILNEILTE SKINEIFQVI 201 SQLLKYGVEK LPINLFNTTL DLIYDLSSES FEFIDHVSNN ELLSQFLNGL 251 SPALHPQANE LTKVLIEGIH CQFLDMKITY DQCNKMIHSV CHSINNIDPV 301 QLVNDINNPV EIGPATSKDE SSKVITKIKD YNAKRNESMI KLQSIEIAID 351 LITAIIEIVA SKYESPESQE VAIPEELINT LTNFLPHVFM ILKDTFTSRI 401 LIGWNNLIWL FVSLSLTELS GELLTTLWSY VTQLDSQDDL SIKIGRMGCI 451 WALLKLIFPD GAFESENRAL INVQMLNNSG FARGIIEEFQ NNNDLELQQK 501 CINVLSTYAM IQGQIDANKE IGQFFIQTLT QLNVRPEILI EMTNSLFQIY 551 GDASYDYNEP IFVRGGFLSI LKDQVVPNLR QQFKMVDKNK NPELKERCHD 601 CFTTLDSFIH YKMNENSTNQ *

Amino Acid Sequence (or in FASTA format)

       1  MGRSKKRSRA SSSRLNPLRK AGSNDNNKDT NVVNKKLQPL LQNLSSVVPN
      51  DRSIALSSIS VLCEDAHMRQ LLLKEKLVPI ILNKLLNDSN SDIVVESFGL
     101  LRNLSLEEGY DVSIYLWRSD IWTSITSNFG RIVESLSALQ AAEQQPQLKP
     151  AGKSKIESKR LLFDFADNLL SLVVALSNGS DDILNEILTE SKINEIFQVI
     201  SQLLKYGVEK LPINLFNTTL DLIYDLSSES FEFIDHVSNN ELLSQFLNGL
     251  SPALHPQANE LTKVLIEGIH CQFLDMKITY DQCNKMIHSV CHSINNIDPV
     301  QLVNDINNPV EIGPATSKDE SSKVITKIKD YNAKRNESMI KLQSIEIAID
     351  LITAIIEIVA SKYESPESQE VAIPEELINT LTNFLPHVFM ILKDTFTSRI
     401  LIGWNNLIWL FVSLSLTELS GELLTTLWSY VTQLDSQDDL SIKIGRMGCI
     451  WALLKLIFPD GAFESENRAL INVQMLNNSG FARGIIEEFQ NNNDLELQQK
     501  CINVLSTYAM IQGQIDANKE IGQFFIQTLT QLNVRPEILI EMTNSLFQIY
     551  GDASYDYNEP IFVRGGFLSI LKDQVVPNLR QQFKMVDKNK NPELKERCHD
     601  CFTTLDSFIH YKMNENSTNQ *

external links for Syo1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Syo1p

1)	Kressler D, et al. (2012) Synchronizing nuclear import of ribosomal proteins with ribosome assembly. Science 338(6107):666-71
2)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3)	Wade CH, et al. (2006) The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes. Yeast 23(4):293-306
4)	Li Z, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41