STP4/YDL048C Protein Information

Standard Name	Stp4p 1
Systematic Name	Ydl048cp
ORF Classification	Verified
Description	Protein containing a Kruppel-type zinc-finger domain; similar to Stp1p, Stp2p; predicted transcription factor; relative distribution to the nucleus increases upon DNA replication stress; STP4 has a paralog, STP3, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description	protein with similarity to Stp1p 2

Experimental Data
Molecules/cell	623 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	490
Molecular Weight (Da)	54,366
Isoelectric Point (pI)	9.47

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Stp4p (InterPro)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006A7F5 \| Q07351 MIPS: YDL048C NCBI: 1279668 \| 3417402 \| 3417404 \| 6320155 \| 74676436 \| NP_010235.1 \| NM_001180107.1 GenBank/EMBL/DDBJ: DAA11807.1 \| Z71781 \| Z74095 \| Z74096

Amino Acid Sequence (or in FASTA format)
1 MLVSSSFASS IDSVMSHETM SLRRNPPFID TPEKMPNPTA SPNGTIHHLI 51 DPSLPLLSST TSSSRSTLSS TLNSPPPPPL TTSYSSYNSS ACQSITSSPT 101 DNTALAHNSK CYFPHSLSPT PLSSNSSSHV ILPPISSFTN LITVAEREFN 151 GRSNSLHANF TSPVPRTVLD HHRHELTFCN PNNTTGFKTI TPSPPTQHQS 201 ILPTAVDNVP RSKSVSSLPV SGFPPLIVKQ QQQQQLNSSS SASALPSIHS 251 PLTNEHTSRY SSSLKDSAKI TKQRKKKECP ICHNFYANLS THKSTHLTPE 301 DRPHKCPICQ RGFARNNDLI RHKKRHWKDE FMQIYARESD NNSGADDQDD 351 TARTSANNDS DDSNDKLAAS SSSEETKLLK KNQLKSLYKI KGAFKCPYNS 401 TLINLDMEVY PHKSRSLYFE PINCHQTGVF SRCDTFKNHL KALHFEYPPK 451 TKKEDRGVVP GKCKHCGLQF PNVDVWLNKH VGKGCGYSYH *

Amino Acid Sequence (or in FASTA format)

       1  MLVSSSFASS IDSVMSHETM SLRRNPPFID TPEKMPNPTA SPNGTIHHLI
      51  DPSLPLLSST TSSSRSTLSS TLNSPPPPPL TTSYSSYNSS ACQSITSSPT
     101  DNTALAHNSK CYFPHSLSPT PLSSNSSSHV ILPPISSFTN LITVAEREFN
     151  GRSNSLHANF TSPVPRTVLD HHRHELTFCN PNNTTGFKTI TPSPPTQHQS
     201  ILPTAVDNVP RSKSVSSLPV SGFPPLIVKQ QQQQQLNSSS SASALPSIHS
     251  PLTNEHTSRY SSSLKDSAKI TKQRKKKECP ICHNFYANLS THKSTHLTPE
     301  DRPHKCPICQ RGFARNNDLI RHKKRHWKDE FMQIYARESD NNSGADDQDD
     351  TARTSANNDS DDSNDKLAAS SSSEETKLLK KNQLKSLYKI KGAFKCPYNS
     401  TLINLDMEVY PHKSRSLYFE PINCHQTGVF SRCDTFKNHL KALHFEYPPK
     451  TKKEDRGVVP GKCKHCGLQF PNVDVWLNKH VGKGCGYSYH *

external links for Stp4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Stp4p

1)	Bohm S, et al. (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9
2)	Abdel-Sater F, et al. (2004) The external amino acid signaling pathway promotes activation of Stp1 and Uga35/Dal81 transcription factors for induction of the AGP1 gene in Saccharomyces cerevisiae. Genetics 166(4):1727-39
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Yang Y, et al. (2010) Identifying cooperative transcription factors by combining ChIP-chip data and knockout data. Cell Res 20(11):1276-8
5)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41