GPR1/YDL035C Protein Information Help

Standard Name Gpr1p 1
Systematic Name Ydl035cp
ORF Classification Verified
Description Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis (1, 2, 3, 4, 5)
Name Description G-Protein coupled Receptor 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 961
Molecular Weight (Da) 110,708
Isoelectric Point (pI) 7.08

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Gpr1p (InterPro)
Transmembrane Domains There are 6 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 13 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012BA32 | Q12361
MIPS: YDL035C
NCBI: 1279681 | 1431015 | 26394417 | 6320170 | NP_010249.1
GenBank/EMBL/DDBJ: DAA11819.1 | Z71781 | Z74083
Amino Acid Sequence (or in FASTA format)
 
       1  MITEGFPPNL NALKGSSLLE KRVDSLRQLN TTTVNQLLGL PGMTSTFTAP
      51  QLLQLRIIAI TASAVSLIAG CLGMFFLSKM DKRRKVFRHD LIAFLIICDF
     101  LKAFILMIYP MIILINNSVY ATPAFFNTLG WFTAFAIEGA DMAIMIFAIH
     151  FAILIFKPNW KWRNKRSGNM EGGLYKKRSY IWPITALVPA ILASLAFINY
     201  NKLNDDSDTT IILDNNNYNF PDSPRQGGYK PWSAWCYLPP KPYWYKIVLS
     251  WGPRYFIIIF IFAVYLSIYI FITSESKRIK AQIGDFNHNV LEEEKEKKKL
     301  FGLGHWGKAK WYFRSYFKLP LLHLLRNLKN FFTISFIDPN EETDDSGSSN
     351  GTFNFGESSN EIPTLFRKTN TGSDENVSAS GGVRLLDYNS AKPLDMSKYA
     401  MSEQPDLERN NPFDCENDIT LNPSELVSKQ KEHKVTFSVE NEGLDTRKSS
     451  MLGHQTFSCQ NSLESPLAMY DNKNDNSDIT SNIKEKGGII NNNSNNDDDD
     501  NNNNNDNDND NNNSNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNSNNIKN
     551  NVDNNNTNPA DNIPTLSNEA FTPSQQFSQE RVNNNADRCE NSSFTNVQQH
     601  FQAQTYKQMK KRRAQIQKNL RAIFIYPLSY IGIWLFPIIA DALQYNHEIK
     651  HGPTMWVTYI DTCVRPLSCL VDVIVYLFKE KPWNYSWAKT ESKYLIEKYI
     701  LKGELGEKEI LKFCHSNWGK RGWYYRGKWK KRKCWKYSTN PLKRILWFVE
     751  RFFKQLFELK LHFSFYDNCD DFEYWENYYS AKDSNDNKRT ESDETKTNSS
     801  DRSLPSNSLE LQAMLNNITA EEVEVPLFWR IIHHIPMLGG IDLDELNRLL
     851  KIRYNNDHFS LPGLKFALNQ NKSHDKHQDV STNSMVKSSF FSSNIVTNDD
     901  ENSIEEDKNL RYSDASASEN YLVKPTIPGT TPDPIIEAQN DNDSSDSSGI
     951  DLIAFLRNGP L*

external links for Gpr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Gpr1p
1) Yun CW, et al.  (1997) G-protein coupled receptor from yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun 240(2):287-92
2) Xue Y, et al.  (1998) GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Galpha subunit and functions in a Ras-independent pathway. EMBO J 17(7):1996-2007
3) Kraakman L, et al.  (1999) A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Mol Microbiol 32(5):1002-12
4) Ansari K, et al.  (1999) Phospholipase C binds to the receptor-like GPR1 protein and controls pseudohyphal differentiation in Saccharomyces cerevisiae. J Biol Chem 274(42):30052-8
5) Pan X and Heitman J  (1999) Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Mol Cell Biol 19(7):4874-87