ARP2/YDL029W Protein Information

Standard Name	Arp2p 1
Systematic Name	Ydl029wp
Alias	Act2p 2
ORF Classification	Verified
Description	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity (2, 3, 4)
Name Description	Actin-Related Protein 4

Experimental Data
Molecules/cell	6650 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	391
Molecular Weight (Da)	44,073
Isoelectric Point (pI)	5.59

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Arp2p (InterPro)
Physical Interactions	There are 174 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000531DB \| P32381 MIPS: YDL029W NCBI: 1279687 \| 1431006 \| 3330 \| 416582 \| 6320175 \| NP_010255.1 \| NM_001180088.1 GenBank/EMBL/DDBJ: DAA11823.1 \| X61502 \| Z71781 \| Z74077

Amino Acid Sequence (or in FASTA format)
1 MDPHNPIVLD QGTGFVKIGR AGENFPDYTF PSIVGRPILR AEERASVATP 51 LKDIMIGDEA SEVRSYLQIS YPMENGIIKN WTDMELLWDY AFFEQMKLPS 101 TSNGKILLTE PPMNPLKNRE KMCEVMFEKY DFGGVYVAIQ AVLALYAQGL 151 SSGVVVDSGD GVTHIVPVYE SVVLSHLTRR LDVAGRDVTR HLIDLLSRRG 201 YAFNRTADFE TVRQIKEKLC YVSYDLDLDT KLARETTALV ESYELPDGRT 251 IKVGQERFEA PECLFQPGLV DVEQPGVGEL LFNTVQSADV DIRSSLYKAI 301 VLSGGSSMYP GLPSRLEKEL KQLWFSRVLH NDPSRLDKFK VRIEDPPRRK 351 HMVFIGGAVL ASIMADKDHM WLSKQEWQES GPSAMTKFGP R*

Amino Acid Sequence (or in FASTA format)

       1  MDPHNPIVLD QGTGFVKIGR AGENFPDYTF PSIVGRPILR AEERASVATP
      51  LKDIMIGDEA SEVRSYLQIS YPMENGIIKN WTDMELLWDY AFFEQMKLPS
     101  TSNGKILLTE PPMNPLKNRE KMCEVMFEKY DFGGVYVAIQ AVLALYAQGL
     151  SSGVVVDSGD GVTHIVPVYE SVVLSHLTRR LDVAGRDVTR HLIDLLSRRG
     201  YAFNRTADFE TVRQIKEKLC YVSYDLDLDT KLARETTALV ESYELPDGRT
     251  IKVGQERFEA PECLFQPGLV DVEQPGVGEL LFNTVQSADV DIRSSLYKAI
     301  VLSGGSSMYP GLPSRLEKEL KQLWFSRVLH NDPSRLDKFK VRIEDPPRRK
     351  HMVFIGGAVL ASIMADKDHM WLSKQEWQES GPSAMTKFGP R*

external links for Arp2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Arp2p

1)	Schroer TA, et al. (1994) Actin-related protein nomenclature and classification. J Cell Biol 127(6 Pt 2):1777-8
2)	Schwob E and Martin RP (1992) New yeast actin-like gene required late in the cell cycle. Nature 355(6356):179-82
3)	Winter D, et al. (1997) The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. Curr Biol 7(7):519-29
4)	Poch O and Winsor B (1997) Who's who among the Saccharomyces cerevisiae actin-related proteins? A classification and nomenclature proposal for a large family. Yeast 13(11):1053-8
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41