RTK1/YDL025C Protein Information Help

Standard Name Rtk1p 1
Systematic Name Ydl025cp
ORF Classification Verified
Description Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description Ribosome biogenesis and TRNA synthetase-associated Kinase 1
Experimental Data
Molecules/cell 861 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 620
Molecular Weight (Da) 69,615
Isoelectric Point (pI) 8.38

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rtk1p (InterPro)
Physical Interactions There are 57 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006B845 | Q12100
MIPS: YDL025C
NCBI: 1430999 | 51012883 | 6320179 | 683672 | 74676523 | NP_010259.1 | NM_001180084.1
GenBank/EMBL/DDBJ: AAT92735.1 | CAA88334.1 | CAA98584.1 | DAA11826.1 | AY692716 | Z48432 | Z74073
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
       1  MVKETPLHSS SSTSLSSLFR PTKLKNLSAK IFNGGGNQSY SKTDDVSRSS
      51  SRSSKKNTDS DQEDQIKYNK PNDRRSTIGK SPQGNGALSK ESHVVASSTL
     101  TGISPTSAKK APIDYSPSRP LPNNHNPVRT GHTVPHLPHS IHNPINYIHQ
     151  GSKDAFHHPH PVRSTAHSNI STVSSAKSDT PSSNLSYQAH MHPVEILQKQ
     201  IEDKHFMDSQ ASTPGSVELQ HNSSSGSDDT SSRKKKSLRL TRFFKKIHND
     251  YHDNHHHHHH HNRGSTPTKP KLNLNTNENI VESNGKALYE TDNPVELLEK
     301  YGIPGRKLGE GASGSVSVVE RTDGKLFACK MFRKPHLNNE GTNQSQLANY
     351  SKKVTTEFCI GSTLHHENIV ETLDMLTEGD TYLLVMEYAP YDFFNLVMSN
     401  LMTQDEVNCY FKQLCHGVNY LHSMGLAHRD LKLDNCVVTK DGILKLIDFG
     451  SAVVFQYPYE DTIVKSHGIV GSDPYLAPEL LKQTSYDPRV ADVWSIAIIF
     501  YCMVLKRFPW KAPKKSFNSF RLFTEEPEDE DDIVRGPNKI LRLLPRHSRT
     551  IIGRMLALEP KQRVLMNDVV KDDWLVSVPS CEVDPTSGDL VEKPKNHKHH
     601  LVTEEELNEL TKQHGNKDSN *                               

external links for Rtk1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains YeastRC Public Image Repository
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Rtk1p
1) Breitkreutz A, et al.  (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328(5981):1043-6
2) Hunter T and Plowman GD  (1997) The protein kinases of budding yeast: six score and more. Trends Biochem Sci 22(1):18-22
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41