NOP1/YDL014W Protein Information

Standard Name	Nop1p
Systematic Name	Ydl014wp
Alias	Lot3p
ORF Classification	Verified
Description	Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin (1, 2, 3)
Name Description	NucleOlar Protein 2, 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	327
Molecular Weight (Da)	34,465
Isoelectric Point (pI)	11.03

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Nop1p (InterPro)
Physical Interactions	There are 306 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052ED0 \| P15646 MIPS: YDL014W NCBI: 119857 \| 1430979 \| 172048 \| 1903277 \| 6320190 \| 683683 \| NP_010270.1 GenBank/EMBL/DDBJ: DAA11835.1 \| J05230 \| Z48432 \| Z74061 \| Z74062
External Classifications	EC: 2.1.1.- [Transferases transferring one-carbon groups methyltransferases]

Amino Acid Sequence (or in FASTA format)
1 MSFRPGSRGG SRGGSRGGFG GRGGSRGGAR GGSRGGFGGR GGSRGGARGG 51 SRGGFGGRGG SRGGARGGSR GGRGGAAGGA RGGAKVVIEP HRHAGVYIAR 101 GKEDLLVTKN MAPGESVYGE KRISVEEPSK EDGVPPTKVE YRVWNPFRSK 151 LAAGIMGGLD ELFIAPGKKV LYLGAASGTS VSHVSDVVGP EGVVYAVEFS 201 HRPGRELISM AKKRPNIIPI IEDARHPQKY RMLIGMVDCV FADVAQPDQA 251 RIIALNSHMF LKDQGGVVIS IKANCIDSTV DAETVFAREV QKLREERIKP 301 LEQLTLEPYE RDHCIVVGRY MRSGLKK*

Amino Acid Sequence (or in FASTA format)

       1  MSFRPGSRGG SRGGSRGGFG GRGGSRGGAR GGSRGGFGGR GGSRGGARGG
      51  SRGGFGGRGG SRGGARGGSR GGRGGAAGGA RGGAKVVIEP HRHAGVYIAR
     101  GKEDLLVTKN MAPGESVYGE KRISVEEPSK EDGVPPTKVE YRVWNPFRSK
     151  LAAGIMGGLD ELFIAPGKKV LYLGAASGTS VSHVSDVVGP EGVVYAVEFS
     201  HRPGRELISM AKKRPNIIPI IEDARHPQKY RMLIGMVDCV FADVAQPDQA
     251  RIIALNSHMF LKDQGGVVIS IKANCIDSTV DAETVFAREV QKLREERIKP
     301  LEQLTLEPYE RDHCIVVGRY MRSGLKK*

external links for Nop1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Nop1p

1)	Tollervey D, et al. (1991) The small nucleolar RNP protein NOP1 (fibrillarin) is required for pre-rRNA processing in yeast. EMBO J 10(3):573-83
2)	Schimmang T, et al. (1989) A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability. EMBO J 8(13):4015-24
3)	Dragon F, et al. (2002) A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature 417(6892):967-70
4)	Henriquez R, et al. (1990) Isolation and sequencing of NOP1. A yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen. J Biol Chem 265(4):2209-15