SLX5/YDL013W Protein Information Help

Standard Name Slx5p 1
Systematic Name Ydl013wp
Alias Hex3p 2 , Uls2p 3
ORF Classification Verified
Description Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers (1, 4, 5, 6, 7)
Name Description Synthetic Lethal of unknown [X] function 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 619
Molecular Weight (Da) 71,070
Isoelectric Point (pI) 6.66

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Slx5p (InterPro)
Physical Interactions There are 73 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012C636 | P32828
MIPS: YDL013W
NCBI: 1430977 | 171668 | 398364839 | 417117 | 683684 | NP_010271.3
GenBank/EMBL/DDBJ: DAA11836.1 | L07745 | Z48432 | Z74061
External Classifications EC: 6.3.2.- [Acid-Amino-Acid Ligases (Peptide Synthases)]
Amino Acid Sequence (or in FASTA format)
 
       1  MHSDTNGRTK SNNSPSDNNP NETVILIDSD KEEDASIREA NLPVRLYPDR
      51  RVGRRRDALN RFVRSDSRSR NSQRTHITAS SERPDFQANN DDITIIREVG
     101  RFFGDDGPID PSAHYVDLDQ EPGSETLETP RTIQVDNTNG YLNDNGNNNE
     151  SDDGLTIVEE RTTRPRVTLN LPGGERLEVT ATTTDIPIRR SFEFQEDLGA
     201  SRRQLLRRSA TRARNLFVDR SDENDEDWTD DTHNLPEAIQ RARRESRMRM
     251  SRRIAERQRR VQQQRVSSDE NISTSIRLQS IRERIQSYTP DIRSAFHRAE
     301  SLHEFRSILQ NVAPITLQEC EEELMALFTE FRNQLLQNWA IDRVRNTQEE
     351  ALRLHREALE RQERTAGRVF HRGTLRESIT NYLNFNGEDG FLSRLWSGPA
     401  LSDADEERHT QNIIDMIQER EERERDVVMK NLMNKTRAQQ EEFEARAASL
     451  PEGYSASFDT TPKMKLDITK NGKEETIIVT DDDLAKTLED IPVCCLCGAE
     501  LGVGIPDDFT GISQKDRGVS FEGLVSKYKF HCPYQTLARP SMLDRDLSKR
     551  TFIASCGHAF CGRCFARIDN AKKKSKMPKK KLAQLKGSAH PDNYGPKLCP
     601  ADSCKKLIRS RGRLKEVYF*

external links for Slx5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains

Complexome


DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Slx5p
1) Mullen JR, et al.  (2001) Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics 157(1):103-18
2) Sternglanz, R.  (1993) Personal Communication, Mortimer Map Edition 12
3) Uzunova K, et al.  (2007) Ubiquitin-dependent Proteolytic Control of SUMO Conjugates. J Biol Chem 282(47):34167-75
4) Wang Z, et al.  (2006) Genetic Analysis Connects SLX5 and SLX8 to the SUMO Pathway in Saccharomyces cerevisiae. Genetics 172(3):1499-509
5) Xie Y, et al.  (2007) The Yeast Hex3{middle dot}Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation. J Biol Chem 282(47):34176-84
6) Ii T, et al.  (2007) The yeast Slx5-Slx8 DNA integrity complex displays ubiquitin ligase activity. Cell Cycle 6(22):2800-9
7) Cook CE, et al.  (2009) The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks. Cell Cycle 8(7):1080-9