NHP6B/YBR089C-A Protein Information 
| Standard Name | Nhp6bp 1 |
|---|---|
| Systematic Name | Ybr089c-ap |
| Alias | Ybr090c-ap |
| ORF Classification | Verified |
| Description | High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7) |
| Name Description | Non-Histone Protein 8 |
| Experimental Data | |
|---|---|
| Molecules/cell | 4590 9 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Nhp6bp (InterPro) |
| Physical Interactions | There are 75 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI0000130038 | P11633 MIPS: YBR089C-A NCBI: 124263184 | 1870101 | 1870104 | 339046261 | 341942236 | 38503394 | 4036 | 45271022 | NP_009647.2 GenBank/EMBL/DDBJ: DAA07210.2 | AY558566 | EF123125 | X15318 | X78993 | Z35957 | Z35959 |
external links for Nhp6bp
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | Organelle DB |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YPL+ |
| Aspergillus (AspGD) | BioPIXIE | MIPS | YeastGFP |
| Candida (CGD) | CYC2008 (complexes) | Pfam domains | YeastRC Public Image Repository |
| Candida (CandidaDB) | Complexome | YeastRC Structure Prediction (Seattle) | |
| YGOB | DIP | ||
| YOGY | GeneMANIA |
References cited on this page View Complete Literature Guide for Nhp6bp
| 1) | Kolodrubetz D and Burgum A (1990) Duplicated NHP6 genes of Saccharomyces cerevisiae encode proteins homologous to bovine high mobility group protein 1. J Biol Chem 265(6):3234-9 |
| 2) | Paull TT, et al. (1996) Yeast HMG proteins NHP6A/B potentiate promoter-specific transcriptional activation in vivo and assembly of preinitiation complexes in vitro. Genes Dev 10(21):2769-81 |
| 3) | Rhoades AR, et al. (2004) Structural features of nucleosomes reorganized by yeast FACT and its HMG box component, Nhp6. Mol Cell Biol 24(9):3907-17 |
| 4) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 5) | Xin H, et al. (2009) yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement. Mol Cell 35(3):365-76 |
| 6) | Stillman DJ (2010) Nhp6: A small but powerful effector of chromatin structure in Saccharomyces cerevisiae. Biochim Biophys Acta 1799(1-2):175-180 |
| 7) | Thomas JO (2001) HMG1 and 2: architectural DNA-binding proteins. Biochem Soc Trans 29(Pt 4):395-401 |
| 8) | Kolodrubetz D, et al. (1988) Amino-terminal sequence of a Saccharomyces cerevisiae nuclear protein, NHP6, shows significant identity to bovine HMG1. FEBS Lett 238(1):175-9 |
| 9) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
