RPL2A/YFR031C-A Protein Information

Standard Name	Rpl2ap
Systematic Name	Yfr031c-ap
Alias	Rpl5bp
ORF Classification	Verified
Description	Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Ribosomal Protein of the Large subunit
Gene Product	L2 4 , L2A 1 , L5A 1 , YL6 1 , rp8 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	254
Molecular Weight (Da)	27,408
Isoelectric Point (pI)	11.74

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rpl2ap (InterPro)
Physical Interactions	There are 190 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052E35 \| P0CX45 MIPS: YFR031C-A NCBI: 315113302 \| 315113527 \| 315113572 \| 338819292 \| 365767252 \| 365767293 \| 398364349 \| 468042 \| 49258840 \| 596084 \| 6322171 \| NP_012246.1 \| NP_116688.3 GenBank/EMBL/DDBJ: DAA12472.1 \| D50617 \| U05820 \| U17359

Amino Acid Sequence (or in FASTA format)
1 MGRVIRNQRK GAGSIFTSHT RLRQGAAKLR TLDYAERHGY IRGIVKQIVH 51 DSGRGAPLAK VVFRDPYKYR LREEIFIANE GVHTGQFIYA GKKASLNVGN 101 VLPLGSVPEG TIVSNVEEKP GDRGALARAS GNYVIIIGHN PDENKTRVRL 151 PSGAKKVISS DARGVIGVIA GGGRVDKPLL KAGRAFHKYR LKRNSWPKTR 201 GVAMNPVDHP HGGGNHQHIG KASTISRGAV SGQKAGLIAA RRTGLLRGSQ 251 KTQD*

Amino Acid Sequence (or in FASTA format)

       1  MGRVIRNQRK GAGSIFTSHT RLRQGAAKLR TLDYAERHGY IRGIVKQIVH
      51  DSGRGAPLAK VVFRDPYKYR LREEIFIANE GVHTGQFIYA GKKASLNVGN
     101  VLPLGSVPEG TIVSNVEEKP GDRGALARAS GNYVIIIGHN PDENKTRVRL
     151  PSGAKKVISS DARGVIGVIA GGGRVDKPLL KAGRAFHKYR LKRNSWPKTR
     201  GVAMNPVDHP HGGGNHQHIG KASTISRGAV SGQKAGLIAA RRTGLLRGSQ
     251  KTQD*

external links for Rpl2ap

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	GeneMANIA
YOGY

References cited on this page View Complete Literature Guide for Rpl2ap

1)	Planta RJ and Mager WH (1998) The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14(5):471-7
2)	Lecompte O, et al. (2002) Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain scale. Nucleic Acids Res 30(24):5382-90
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Jenner L, et al. (2012) Crystal structure of the 80S yeast ribosome. Curr Opin Struct Biol 22(6):759-67