IRC7/YFR055W Protein Information

Standard Name	Irc7p 1
Systematic Name	Yfr055wp
ORF Classification	Uncharacterized
Description	Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner (1, 2, 3, 4, 5)
Name Description	Increased Recombination Centers 1

Experimental Data
Molecules/cell	2610 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	340
Molecular Weight (Da)	36,971
Isoelectric Point (pI)	6.07

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Irc7p (InterPro)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012EF69 \| P43623 MIPS: YFR055W NCBI: 1170931 \| 14318580 \| 836811 \| NP_116714.1 GenBank/EMBL/DDBJ: DAA12497.1 \| D50617
External Classifications	EC: 4.4.1.8 [Cystathionine beta-lyase]

Amino Acid Sequence (or in FASTA format)
1 MIDRTELSKF GITTQLSVIG RNPDEQSGFV NPPLYKGSTI ILKKLSDLEQ 51 RKGRFYGTAG SPTIDNLENA WTHLTGGAGT VLSASGLGSI SLALLALSKA 101 GDHILMTDSV YVPTRMLCDG LLAKFGVETD YYDPSIGKDI EKLVKPNTTV 151 IFLESPGSGT MEVQDIPALV SVAKKHGIKT ILDNTWATPL FFDAHAHGID 201 ISVEAGTKYL GGHSDLLIGL ASANEECWPL LRSTYDAMAM LPGAEDCQLA 251 LRGMRTLHLR LKEVERKALD LAAWLGNRDE VEKVLHPAFE DCPGHEYWVR 301 DYKGSSGLFS IVLKNGFTRA GLEKMVEGMK VLQLGFSWGG *

Amino Acid Sequence (or in FASTA format)

       1  MIDRTELSKF GITTQLSVIG RNPDEQSGFV NPPLYKGSTI ILKKLSDLEQ
      51  RKGRFYGTAG SPTIDNLENA WTHLTGGAGT VLSASGLGSI SLALLALSKA
     101  GDHILMTDSV YVPTRMLCDG LLAKFGVETD YYDPSIGKDI EKLVKPNTTV
     151  IFLESPGSGT MEVQDIPALV SVAKKHGIKT ILDNTWATPL FFDAHAHGID
     201  ISVEAGTKYL GGHSDLLIGL ASANEECWPL LRSTYDAMAM LPGAEDCQLA
     251  LRGMRTLHLR LKEVERKALD LAAWLGNRDE VEKVLHPAFE DCPGHEYWVR
     301  DYKGSSGLFS IVLKNGFTRA GLEKMVEGMK VLQLGFSWGG *

external links for Irc7p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Irc7p

1)	Alvaro D, et al. (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228
2)	Hansen J and Johannesen PF (2000) Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae. Mol Gen Genet 263(3):535-42
3)	Gross C, et al. (2000) Identification of the copper regulon in Saccharomyces cerevisiae by DNA microarrays. J Biol Chem 275(41):32310-6
4)	Scherens B, et al. (2006) Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability in the short and long term. FEMS Yeast Res 6(5):777-91
5)	Roncoroni M, et al. (2011) The yeast IRC7 gene encodes a beta-lyase responsible for production of the varietal thiol 4-mercapto-4-methylpentan-2-one in wine. Food Microbiol 28(5):926-35
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41