BNA6/YFR047C Protein Information

Standard Name	Bna6p 1
Systematic Name	Yfr047cp
Alias	Qpt1p 2
ORF Classification	Verified
Description	Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p (1, 3)
Name Description	Biosynthesis of Nicotinic Acid 1

Experimental Data
Molecules/cell	2660 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	295
Molecular Weight (Da)	32,365
Isoelectric Point (pI)	5.69

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Bna6p (InterPro)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012FC9F \| P43619 MIPS: YFR047C NCBI: 1171637 \| 170785208 \| 170785209 \| 171849071 \| 171849072 \| 171849073 \| 171849074 \| 398364399 \| 836802 \| NP_602317.3 GenBank/EMBL/DDBJ: DAA12490.1 \| D50617
External Classifications	EC: 2.4.2.19 [Nicotinate-nucleotide diphosphorylase (carboxylating)]

Amino Acid Sequence (or in FASTA format)
1 MPVYEHLLPV NGAWRQDVTN WLSEDVPSFD FGGYVVGSDL KEANLYCKQD 51 GMLCGVPFAQ EVFNQCELQV EWLFKEGSFL EPSKNDSGKI VVAKITGPAK 101 NILLAERTAL NILSRSSGIA TASHKIISLA RSTGYKGTIA GTRKTTPGLR 151 RLEKYSMLVG GCDTHRYDLS SMVMLKDNHI WATGSITNAV KNARAVCGFA 201 VKIEVECLSE DEATEAIEAG ADVIMLDNFK GDGLKMCAQS LKNKWNGKKH 251 FLLECSGGLN LDNLEEYLCD DIDIYSTSSI HQGTPVIDFS LKLAH*

Amino Acid Sequence (or in FASTA format)

       1  MPVYEHLLPV NGAWRQDVTN WLSEDVPSFD FGGYVVGSDL KEANLYCKQD
      51  GMLCGVPFAQ EVFNQCELQV EWLFKEGSFL EPSKNDSGKI VVAKITGPAK
     101  NILLAERTAL NILSRSSGIA TASHKIISLA RSTGYKGTIA GTRKTTPGLR
     151  RLEKYSMLVG GCDTHRYDLS SMVMLKDNHI WATGSITNAV KNARAVCGFA
     201  VKIEVECLSE DEATEAIEAG ADVIMLDNFK GDGLKMCAQS LKNKWNGKKH
     251  FLLECSGGLN LDNLEEYLCD DIDIYSTSSI HQGTPVIDFS LKLAH*

external links for Bna6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Bna6p

1)	Panozzo C, et al. (2002) Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Lett 517(1-3):97-102
2)	Lin SJ, et al. (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289(5487):2126-8
3)	Bedalov A, et al. (2003) NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Mol Cell Biol 23(19):7044-54
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41