KEG1/YFR042W Protein Information

Standard Name	Keg1p 1
Systematic Name	Yfr042wp
ORF Classification	Verified
Description	Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability (1, 2)
Name Description	Kre6-binding ER protein responsible for Glucan synthesis 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	200
Molecular Weight (Da)	23,555
Isoelectric Point (pI)	10.5

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Keg1p (InterPro)
Transmembrane Domains	There are 4 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013AEE1 \| P43614 MIPS: YFR042W NCBI: 1176019 \| 14318567 \| 146760351 \| 836797 \| NP_116700.1 GenBank/EMBL/DDBJ: DAA12485.1 \| AB303676 \| D50617

Amino Acid Sequence (or in FASTA format)
1 MAGIKLTHKL YQYYQLATSF LYAALLIRWL ILMPLVGSRF LPGGIHEFLI 51 YLMFYSSIME VIWLLRFHGF KYGLLSRTFL KDLNFIYLVS VIHFYDDYEH 101 ALILKNASYS SFIISLSLSQ AYCHWCKLFK RKGVKERTLV WKVNTFVTLP 151 ILYLSEFALL LLNIQVKNYH STPTLDIINR VVLLAYFPVL LTAYKKLLTK 201 *

Amino Acid Sequence (or in FASTA format)

       1  MAGIKLTHKL YQYYQLATSF LYAALLIRWL ILMPLVGSRF LPGGIHEFLI
      51  YLMFYSSIME VIWLLRFHGF KYGLLSRTFL KDLNFIYLVS VIHFYDDYEH
     101  ALILKNASYS SFIISLSLSQ AYCHWCKLFK RKGVKERTLV WKVNTFVTLP
     151  ILYLSEFALL LLNIQVKNYH STPTLDIINR VVLLAYFPVL LTAYKKLLTK
     201  *

external links for Keg1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Keg1p

1)	Nakamata K, et al. (2007) KEG1/YFR042w Encodes a Novel Kre6-binding Endoplasmic Reticulum Membrane Protein Responsible for beta-1,6-Glucan Synthesis in Saccharomyces cerevisiae. J Biol Chem 282(47):34315-24
2)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91