GSY1/YFR015C Protein Information Help

Standard Name Gsy1p
Systematic Name Yfr015cp
ORF Classification Verified
Description Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress (1, 2, 3, 4, 5, 6, 7)
Name Description Glycogen SYnthase 2
Experimental Data
Molecules/cell 6300 8
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 708
Molecular Weight (Da) 80,510
Isoelectric Point (pI) 5.93

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Gsy1p (InterPro)
Physical Interactions There are 29 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000016831E | P23337
MIPS: YFR015C
NCBI: 136753 | 14318537 | 172870 | 836770 | NP_116670.1
GenBank/EMBL/DDBJ: DAA12456.1 | D50617 | M60919
External Classifications EC: 2.4.1.11 [Glycogen(starch) synthase]
Amino Acid Sequence (or in FASTA format)
 
       1  MARDLQNHLL FEVATEVTNR VGGIYSVLKS KAPVTVAQYG DNYTLLGPLN
      51  KATYESEVEK LDWEDESIFP EELLPIQKTL MSMREKGVNF VYGNWLIEGA
     101  PRVILFELDS VRHFLNEWKA DLWSLVGIPS PEHDHETNDA ILLGYVVVWF
     151  LGEVSKLDSS HAIIGHFHEW LAGVALPLCR KKRIDVVTIF TTHATLLGRY
     201  LCAAGDVDFY NNLQYFDVDQ EAGKRGIYHR YCIERAAAHT ADVFTTVSQI
     251  TALEAEHLLK RKPDGILPNG LNVVKFQAVH EFQNLHALKK DKINDFVRGH
     301  FHGCFDFDLD NTVYFFIAGR YEYKNKGADM FIESLARLNY RLKVSGSKKT
     351  VVAFLIMPAK TNSFTVEALK SQAIVKSLEN TVNEVTASIG KRIFEHTMRY
     401  PHNGLESELP TNLDELLKSS EKVLLKKRVL ALRRPYGELP PVVTHNMCDD
     451  ANDPILNQIR HVRLFNDSSD RVKVIFHPEF LNANNPILGL DYDEFVRGCH
     501  LGVFPSYYEP WGYTPAECTV MGVPSITTNV SGFGAYMEDL IETDQAKDYG
     551  IYIVDRRFKS PDESVEQLAD YMEEFVNKTR RQRINQRNRT ERLSDLLDWK
     601  RMGLEYVKAR QLGLRRAYPE QFKQLVGETI SDANMNTLAG GKKFKIARPL
     651  SVPGSPKVRS NSTVYMTPGD LGTLQDANNA DDYFNLSTNG AIDNDDDDND
     701  TSAYYEDN*

external links for Gsy1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Gsy1p
1) Parrou JL, et al.  (1999) Dynamic responses of reserve carbohydrate metabolism under carbon and nitrogen limitations in Saccharomyces cerevisiae. Yeast 15(3):191-203
2) Farkas I, et al.  (1990) Isolation of the GSY1 gene encoding yeast glycogen synthase and evidence for the existence of a second gene. J Biol Chem 265(34):20879-86
3) Peng ZY, et al.  (1990) Purification and characterization of glycogen synthase from a glycogen-deficient strain of Saccharomyces cerevisiae. J Biol Chem 265(23):13871-7
4) Ni HT and LaPorte DC  (1995) Response of a yeast glycogen synthase gene to stress. Mol Microbiol 16(6):1197-205
5) Unnikrishnan I, et al.  (2003) Multiple positive and negative elements involved in the regulation of expression of GSY1 in Saccharomyces cerevisiae. J Biol Chem 278(29):26450-7
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
7) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
8) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41