FAR7/YFR008W Protein Information

Standard Name	Far7p 1
Systematic Name	Yfr008wp
ORF Classification	Verified
Description	Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress (1, 2)
Name Description	Factor ARrest 3

Experimental Data
Molecules/cell	486 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	221
Molecular Weight (Da)	25,915
Isoelectric Point (pI)	6

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Far7p (InterPro)
Physical Interactions	There are 21 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013AE89 \| P43592 MIPS: YFR008W NCBI: 1175979 \| 14318530 \| 836763 \| NP_116663.1 GenBank/EMBL/DDBJ: DAA12448.1 \| D50617

Amino Acid Sequence (or in FASTA format)
1 MSDQINVLSM QQQQQQQQQQ QQVYMSPQAE NLNHMYLLVN KLVKQLRENQ 51 AEKAKILRNI DILSGSLNKY ETSEEPHDTT ENIALFNRFL EQRGKAPITE 101 KEQLSNNLDE NAKDDVMLGV LKRQNSMLRK SLQESKQVTL ESMDLLSYSE 151 DSLNYIVAQL RGNILMHHKE TIKLIRQKFQ TETIPLEDEE FKMYLENVNG 201 LQKLTDISHT YRLLLRLHAQ D*

Amino Acid Sequence (or in FASTA format)

       1  MSDQINVLSM QQQQQQQQQQ QQVYMSPQAE NLNHMYLLVN KLVKQLRENQ
      51  AEKAKILRNI DILSGSLNKY ETSEEPHDTT ENIALFNRFL EQRGKAPITE
     101  KEQLSNNLDE NAKDDVMLGV LKRQNSMLRK SLQESKQVTL ESMDLLSYSE
     151  DSLNYIVAQL RGNILMHHKE TIKLIRQKFQ TETIPLEDEE FKMYLENVNG
     201  LQKLTDISHT YRLLLRLHAQ D*

external links for Far7p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Far7p

1)	Kemp HA and Sprague Jr GF Jr (2003) Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Mol Cell Biol 23(5):1750-63
2)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
3)	Chang F and Herskowitz I (1990) Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2. Cell 63(5):999-1011
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41