MSH4/YFL003C Protein Information Help

Standard Name Msh4p
Systematic Name Yfl003cp
ORF Classification Verified
Description Protein involved in meiotic recombination; required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein (1, 2)
Name Description MutS Homolog
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 878
Molecular Weight (Da) 99,224
Isoelectric Point (pI) 7.24

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Msh4p (InterPro)
Physical Interactions There are 15 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000530F8 | P40965
MIPS: YFL003C
NCBI: 14318519 | 308153466 | 563198 | 730066 | 836751 | NP_116652.1 | NM_001179963.1
GenBank/EMBL/DDBJ: AAA65234.1 | BAA09235.1 | DAA12436.1 | D50617 | U13999
Amino Acid Sequence (or in FASTA format)
       1  MSESNLSSFI STNYFNLRSA ANSSNSISKP STKKSIRNQK SPTNISSWAL
      51  KKKTLQIAET TWENNEKDST HSHYLMTGSM ASRTATSLSR YSTNASLLGP
     101  SIDCVLCCIY EVPRDISTRI GLCIINCNTG QMYLSDFMDS QIYIRVVHKL
     151  QIYQPTEILI PSSSLAPTVS KLATMIKFNV AETVKIEEGS RKCFNSQDGL
     201  AAITKYLMDD TKKDLKIEEI IDKTFALCAA SAAISYMEEI ISKSSRNLNA
     251  FRKLRIQFEG TENTMLIDSK TVRGLELVEN KLDKNGISLW KFLDTTSTKM
     301  GQRSLRNSIL QPLTDRGSIE MRLEALEELK ANDDLLQKLR LEMKSLPDLD
     351  KLFSRLLCIN HSAIKPDQRI NYVLLLKETL QSVKSLKDAL NDQLIQSRLI
     401  SETKKIFNND AIMEIEKLIN SCINEDCVWA SSAIQLLNQR SYAVKSDSNG
     451  LLDVSRQIYK EVKEEFFREV EDLTAKNKIN LDHNYDSARG FYLRIKRQEF
     501  TDDVATLPDV FISRTIKKNY IECTTLNIIK KNARLKEVME EILLLSEETV
     551  DELLDKIATH ISELFMIAEA VAILDLVCSF TYNLKENNYT IPIFTNNLLI
     601  RDSRHPLLEK VLKNFVPNTI SSTKHSSSLQ IITGCNMSGK SVYLKQVALI
     651  CIMAQMGSGI PALYGSFPVF KRLHARVCND SMELTSSNFG FEMKEMAYFL
     701  DDINTETLLI LDELGRGSSI ADGFCVSLAV TEHLLRTEAT VFLSTHFQDI
     751  PKIMSKKPAV SHLHMDAVLL NDNSVKMNYQ LTQKSVAIEN SGIRVVKKIF
     801  NPDIIAEAYN IHSLLKIAKA RTENEDSNGV VDQKTINQMK RIHNLVAILK
     851  ECAGNEKEPL TLGKLKEINS DFIENFEE*                       

external links for Msh4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Msh4p
1) Ross-Macdonald P and Roeder GS  (1994) Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction. Cell 79(6):1069-80
2) Novak JE, et al.  (2001) The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution. Genetics 158(3):1013-25