SMC1/YFL008W Protein Information Help

Standard Name Smc1p 1
Systematic Name Yfl008wp
Alias Chl10p
ORF Classification Verified
Description Subunit of the multiprotein cohesin complex; essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure (2, 3, 4)
Name Description Stability of MiniChromosomes 3, 5
Experimental Data
Molecules/cell 5710 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,225
Molecular Weight (Da) 141,279
Isoelectric Point (pI) 6.41

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Smc1p (InterPro)
Physical Interactions There are 109 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000530B0 | P32908
MIPS: YFL008W
NCBI: 14318514 | 172621 | 417778 | 55670515 | 55670516 | 55670517 | 55670518 | 836746 | NP_116647.1 | NM_001179958.1
GenBank/EMBL/DDBJ: AAA16595.1 | BAA09230.1 | DAA12432.1 | D50617 | L00602
Amino Acid Sequence (or in FASTA format)
       1  MGRLVGLELS NFKSYRGVTK VGFGESNFTS IIGPNGSGKS NMMDAISFVL
      51  GVRSNHLRSN ILKDLIYRGV LNDENSDDYD NEGAASSNPQ SAYVKAFYQK
     101  GNKLVELMRI ISRNGDTSYK IDGKTVSYKD YSIFLENENI LIKAKNFLVF
     151  QGDVEQIAAQ SPVELSRMFE EVSGSIQYKK EYEELKEKIE KLSKSATESI
     201  KNRRRIHGEL KTYKEGINKN EEYRKQLDKK NELQKFQALW QLYHLEQQKE
     251  ELTDKLSALN SEISSLKGKI NNEMKSLQRS KSSFVKESAV ISKQKSKLDY
     301  IFKDKEKLVS DLRLIKVPQQ AAGKRISHIE KRIESLQKDL QRQKTYVERF
     351  ETQLKVVTRS KEAFEEEIKQ SARNYDKFKL NENDLKTYNC LHEKYLTEGG
     401  SILEEKIAVL NNDKREIQEE LERFNKRADI SKRRITEELS ITGEKLDTQL
     451  NDLRVSLNEK NALHTERLHE LKKLQSDIES ANNQEYDLNF KLRETLVKID
     501  DLSANQRETM KERKLRENIA MLKRFFPGVK GLVHDLCHPK KEKYGLAVST
     551  ILGKNFDSVI VENLTVAQEC IAFLKKQRAG TASFIPLDTI ETELPTLSLP
     601  DSQDYILSIN AIDYEPEYEK AMQYVCGDSI ICNTLNIAKD LKWKKGIRGK
     651  LVTIEGALIH KAGLMTGGIS GDANNRWDKE EYQSLMSLKD KLLIQIDELS
     701  NGQRSNSIRA REVENSVSLL NSDIANLRTQ VTQQKRSLDE NRLEIKYHND
     751  LIEKEIQPKI TELKKKLDDL ENTKDNLVKE KEALQNNIFK EFTSKIGFTI
     801  KEYENHSGEL MRQQSKELQQ LQKQILTVEN KLQFETDRLS TTQRRYEKAQ
     851  KDLENAQVEM KSLEEQEYAI EMKIGSIESK LEEHKNHLDE LQKKFVTKQS
     901  ELNSSEDILE DMNSNLQVLK RERDGIKEDI EKFDLERVTA LKNCKISNIN
     951  IPISSETTID DLPISSTDNE AITISNSIDI NYKGLPKKYK ENNTDSARKE
    1001  LEQKIHEVEE ILNELQPNAR ALERYDEAEG RFEVINNETE QLKAEEKKIL
    1051  NQFLKIKKKR KELFEKTFDY VSDHLDAIYR ELTKNPNSNV ELAGGNASLT
    1101  IEDEDEPFNA GIKYHATPPL KRFKDMEYLS GGEKTVAALA LLFAINSYQP
    1151  SPFFVLDEVD AALDITNVQR IAAYIRRHRN PDLQFIVISL KNTMFEKSDA
    1201  LVGVYRQQQE NSSKIITLDL SNYAE*                          

external links for Smc1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains YeastRC Public Image Repository
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Smc1p
1) Larionov, V.  (1989) Personal Communication, Mortimer Map Edition 10
2) Akhmedov AT, et al.  (1998) Structural maintenance of chromosomes protein C-terminal domains bind preferentially to DNA with secondary structure. J Biol Chem 273(37):24088-94
3) Strunnikov AV, et al.  (1993) SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family. J Cell Biol 123(6 Pt 2):1635-48
4) Schar P, et al.  (2004) SMC1 coordinates DNA double-strand break repair pathways. Nucleic Acids Res 32(13):3921-9
5) Larionov VL, et al.  (1985) A mutant of Saccharomyces cerevisiae with impaired maintenance of centromeric plasmids. Curr Genet 10(1):15-20
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41