CAF16/YFL028C Protein Information

Standard Name	Caf16p 1
Systematic Name	Yfl028cp
ORF Classification	Verified
Description	Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator (1, 2)
Name Description	CCR4 Associated Factor 1

Experimental Data
Molecules/cell	1620 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	289
Molecular Weight (Da)	33,090
Isoelectric Point (pI)	6.63

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Caf16p (InterPro)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013ADF6 \| P43569 MIPS: YFL028C NCBI: 1175936 \| 14318491 \| 836726 \| NP_116625.1 GenBank/EMBL/DDBJ: DAA12412.1 \| D50617

Amino Acid Sequence (or in FASTA format)
1 MVSQFAIEVR NLTYKFKESS DPSVVDINLQ IPWNTRSLVV GANGAGKSTL 51 LKLLSGKHLC LDGKILVNGL DPFSPLSMNQ VDDDESVEDS TNYQTTTYLG 101 TEWCHMSIIN RDIGVLELLK SIGFDHFRER GERLVRILDI DVRWRMHRLS 151 DGQKRRVQLA MGLLKPWRVL LLDEVTVDLD VIARARLLEF LKWETETRRC 201 SVVYATHIFD GLAKWPNQVY HMKSGKIVDN LDYQKDVEFS EVVNAKVNGQ 251 VAFENDNNKV VISKVNSLHP LALEWLKRDN QIPDKEIGI*

Amino Acid Sequence (or in FASTA format)

       1  MVSQFAIEVR NLTYKFKESS DPSVVDINLQ IPWNTRSLVV GANGAGKSTL
      51  LKLLSGKHLC LDGKILVNGL DPFSPLSMNQ VDDDESVEDS TNYQTTTYLG
     101  TEWCHMSIIN RDIGVLELLK SIGFDHFRER GERLVRILDI DVRWRMHRLS
     151  DGQKRRVQLA MGLLKPWRVL LLDEVTVDLD VIARARLLEF LKWETETRRC
     201  SVVYATHIFD GLAKWPNQVY HMKSGKIVDN LDYQKDVEFS EVVNAKVNGQ
     251  VAFENDNNKV VISKVNSLHP LALEWLKRDN QIPDKEIGI*

external links for Caf16p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Caf16p

1)	Liu HY, et al. (2001) Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme. J Biol Chem 276(10):7541-8
2)	Bauer BE, et al. (1999) Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance. Biochim Biophys Acta 1461(2):217-36
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41