HAC1/YFL031W Protein Information 
| Standard Name | Hac1p 1 |
|---|---|
| Systematic Name | Yfl031wp |
| Alias | Ern4p 1 , Ire15p 2 |
| ORF Classification | Verified |
| Description | Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress (1, 10, 11, 12, 3, 4, 5, 6, 7, 8, 9) |
| Name Description | Homologous to Atf/Creb1 4 |
| Experimental Data | |
|---|---|
| Molecules/cell | 8970 13 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Hac1p (InterPro) |
| Physical Interactions | There are 17 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI0000157F61 | P41546 MIPS: YFL031W NCBI: 115502395 | 1170163 | 14318488 | 1944391 | 2804271 | 786181 | NP_116622.1 GenBank/EMBL/DDBJ: DAA12409.1 | D26506 | D50617 | D86413 |
external links for Hac1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | Organelle DB |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YPL+ |
| YGOB | BioPIXIE | MIPS | YeastGFP |
| YOGY | CYC2008 (complexes) | Pfam domains | YeastRC Public Image Repository |
| Complexome | YeastRC Structure Prediction (Seattle) | ||
| DIP | |||
| GeneMANIA | |||
| YeastRC Two-Hybrid (Seattle) |
References cited on this page View Complete Literature Guide for Hac1p
| 1) | Mori K, et al. (1996) Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway. Genes Cells 1(9):803-17 |
| 2) | Nikawa J, et al. (1997) Suppression of the Saccharomyces cerevisiae hac1/ire15 mutation by yeast genes and human cDNAs. Gene 201(1-2):5-10 |
| 3) | Welihinda AA, et al. (2000) The transcriptional co-activator ADA5 is required for HAC1 mRNA processing in vivo. J Biol Chem 275(5):3377-81 |
| 4) | Nojima H, et al. (1994) Hac1: a novel yeast bZIP protein binding to the CRE motif is a multicopy suppressor for cdc10 mutant of Schizosaccharomyces pombe. Nucleic Acids Res 22(24):5279-88 |
| 5) | Cox JS and Walter P (1996) A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87(3):391-404 |
| 6) | Kawahara T, et al. (1997) Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response. Mol Biol Cell 8(10):1845-62 |
| 7) | Sidrauski C and Walter P (1997) The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90(6):1031-9 |
| 8) | Kaufman RJ (1999) Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13(10):1211-33 |
| 9) | Mori K, et al. (1998) Palindrome with spacer of one nucleotide is characteristic of the cis-acting unfolded protein response element in Saccharomyces cerevisiae. J Biol Chem 273(16):9912-20 |
| 10) | Chapman RE and Walter P (1997) Translational attenuation mediated by an mRNA intron. Curr Biol 7(11):850-9 |
| 11) | Gonzalez TN, et al. (1999) Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J 18(11):3119-32 |
| 12) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 13) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
