MOB2/YFL034C-B Protein Information

Standard Name	Mob2p 1
Systematic Name	Yfl034c-bp
Alias	Yfl035cp , Yfl035c-ap
ORF Classification	Verified
Description	Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p (2, 3, 4)
Name Description	Mps One Binder 1

Experimental Data
Molecules/cell	2250 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	287
Molecular Weight (Da)	33,276
Isoelectric Point (pI)	10.43

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mob2p (InterPro)
Physical Interactions	There are 18 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000168319 \| P43563 MIPS: YFL034C-B NCBI: 116242630 \| 1175942 \| 14318483 \| 836719 \| NP_116618.1 GenBank/EMBL/DDBJ: DAA12405.1 \| D50617

Amino Acid Sequence (or in FASTA format)
1 MSFFNFKAFG RNSKKNKNQP LNVAQPPAMN TIYSSPHSSN SRLSLRNKHH 51 SPKRHSQTSF PAQKSTPQSQ QLTSTTPQSQ QQEASERSES QQIMFLSEPF 101 VRTALVKGSF KTIVQLPKYV DLGEWIALNV FEFFTNLNQF YGVVAEYVTP 151 DAYPTMNAGP HTDYLWLDAN NRQVSLPASQ YIDLALTWIN NKVNDKNLFP 201 TKNGLPFPQQ FSRDVQRIMV QMFRIFAHIY HHHFDKIVHL SLEAHWNSFF 251 SHFISFAKEF KIIDRKEMAP LLPLIESFEK QGKIIYN*

Amino Acid Sequence (or in FASTA format)

       1  MSFFNFKAFG RNSKKNKNQP LNVAQPPAMN TIYSSPHSSN SRLSLRNKHH
      51  SPKRHSQTSF PAQKSTPQSQ QLTSTTPQSQ QQEASERSES QQIMFLSEPF
     101  VRTALVKGSF KTIVQLPKYV DLGEWIALNV FEFFTNLNQF YGVVAEYVTP
     151  DAYPTMNAGP HTDYLWLDAN NRQVSLPASQ YIDLALTWIN NKVNDKNLFP
     201  TKNGLPFPQQ FSRDVQRIMV QMFRIFAHIY HHHFDKIVHL SLEAHWNSFF
     251  SHFISFAKEF KIIDRKEMAP LLPLIESFEK QGKIIYN*

external links for Mob2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Mob2p

1)	Luca FC and Winey M (1998) MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Mol Biol Cell 9(1):29-46
2)	Weiss EL, et al. (2002) The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. J Cell Biol 158(5):885-900
3)	Nelson B, et al. (2003) RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol Biol Cell 14(9):3782-803
4)	Schneper L, et al. (2004) The Ras/protein kinase A pathway acts in parallel with the Mob2/Cbk1 pathway to effect cell cycle progression and proper bud site selection. Eukaryot Cell 3(1):108-20
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41