YPT1/YFL038C Protein Information

Standard Name	Ypt1p 1
Systematic Name	Yfl038cp
ORF Classification	Verified
Description	Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) (2, 3) Also known as: YP2
Name Description	Yeast Protein Two 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	206
Molecular Weight (Da)	23,214
Isoelectric Point (pI)	5.01

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ypt1p (InterPro)
Physical Interactions	There are 87 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F9F \| P01123 MIPS: YFL038C NCBI: 1176710 \| 14318480 \| 193885330 \| 193885336 \| 193885342 \| 193885348 \| 4293 \| 45270824 \| 55670317 \| 73535739 \| 836716 \| 88192430 \| NP_116615.1 GenBank/EMBL/DDBJ: DAA12402.1 \| AY558467 \| D50617 \| X00209

Amino Acid Sequence (or in FASTA format)
1 MNSEYDYLFK LLLIGNSGVG KSCLLLRFSD DTYTNDYIST IGVDFKIKTV 51 ELDGKTVKLQ IWDTAGQERF RTITSSYYRG SHGIIIVYDV TDQESFNGVK 101 MWLQEIDRYA TSTVLKLLVG NKCDLKDKRV VEYDVAKEFA DANKMPFLET 151 SALDSTNVED AFLTMARQIK ESMSQQNLNE TTQKKEDKGN VNLKGQSLTN 201 TGGGCC*

Amino Acid Sequence (or in FASTA format)

       1  MNSEYDYLFK LLLIGNSGVG KSCLLLRFSD DTYTNDYIST IGVDFKIKTV
      51  ELDGKTVKLQ IWDTAGQERF RTITSSYYRG SHGIIIVYDV TDQESFNGVK
     101  MWLQEIDRYA TSTVLKLLVG NKCDLKDKRV VEYDVAKEFA DANKMPFLET
     151  SALDSTNVED AFLTMARQIK ESMSQQNLNE TTQKKEDKGN VNLKGQSLTN
     201  TGGGCC*

external links for Ypt1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Ypt1p

1)	Gallwitz D, et al. (1983) A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene product. Nature 306(5944):704-7
2)	Miaczynska M, et al. (1997) The yeast Rab escort protein binds intracellular membranes in vivo and in vitro. J Biol Chem 272(27):16972-7
3)	Morsomme P and Riezman H (2002) The Rab GTPase Ypt1p and tethering factors couple protein sorting at the ER to vesicle targeting to the Golgi apparatus. Dev Cell 2(3):307-17