PTR2/YKR093W Protein Information

Standard Name	Ptr2p 1
Systematic Name	Ykr093wp
ORF Classification	Verified
Description	Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p (2, 3)
Name Description	Peptide TRansport 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	601
Molecular Weight (Da)	68,043
Isoelectric Point (pI)	5.14

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ptr2p (InterPro)
Transmembrane Domains	There are 11 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001329B5 \| P32901 MIPS: YKR093W NCBI: 450553 \| 453646 \| 486583 \| 548630 \| 6322946 \| NP_013019.1 GenBank/EMBL/DDBJ: DAA09243.1 \| L11994 \| X73541 \| Z28318
External Classifications	TC: 2.A.17.2

Amino Acid Sequence (or in FASTA format)
1 MLNHPSQGSD DAQDEKQGDF PVIEEEKTQA VTLKDSYVSD DVANSTERYN 51 LSPSPEDEDF EGPTEEEMQT LRHVGGKIPM RCWLIAIVEL SERFSYYGLS 101 APFQNYMEYG PNDSPKGVLS LNSQGATGLS YFFQFWCYVT PVFGGYVADT 151 FWGKYNTICC GTAIYIAGIF ILFITSIPSV GNRDSAIGGF IAAIILIGIA 201 TGMIKANLSV LIADQLPKRK PSIKVLKSGE RVIVDSNITL QNVFMFFYFM 251 INVGSLSLMA TTELEYHKGF WAAYLLPFCF FWIAVVTLIF GKKQYIQRPI 301 GDKVIAKSFK VCWILTKNKF DFNAAKPSVH PEKNYPWNDK FVDEIKRALA 351 ACKVFIFYPI YWTQYGTMIS SFITQASMME LHGIPNDFLQ AFDSIALIIF 401 IPIFEKFVYP FIRRYTPLKP ITKIFFGFMF GSFAMTWAAV LQSFVYKAGP 451 WYNEPLGHNT PNHVHVCWQI PAYVLISFSE IFASITGLEY AYSKAPASMK 501 SFIMSIFLLT NAFGSAIGCA LSPVTVDPKF TWLFTGLAVA CFISGCLFWL 551 CFRKYNDTEE EMNAMDYEEE DEFDLNPISA PKANDIEILE PMESLRSTTK 601 Y*

Amino Acid Sequence (or in FASTA format)

       1  MLNHPSQGSD DAQDEKQGDF PVIEEEKTQA VTLKDSYVSD DVANSTERYN
      51  LSPSPEDEDF EGPTEEEMQT LRHVGGKIPM RCWLIAIVEL SERFSYYGLS
     101  APFQNYMEYG PNDSPKGVLS LNSQGATGLS YFFQFWCYVT PVFGGYVADT
     151  FWGKYNTICC GTAIYIAGIF ILFITSIPSV GNRDSAIGGF IAAIILIGIA
     201  TGMIKANLSV LIADQLPKRK PSIKVLKSGE RVIVDSNITL QNVFMFFYFM
     251  INVGSLSLMA TTELEYHKGF WAAYLLPFCF FWIAVVTLIF GKKQYIQRPI
     301  GDKVIAKSFK VCWILTKNKF DFNAAKPSVH PEKNYPWNDK FVDEIKRALA
     351  ACKVFIFYPI YWTQYGTMIS SFITQASMME LHGIPNDFLQ AFDSIALIIF
     401  IPIFEKFVYP FIRRYTPLKP ITKIFFGFMF GSFAMTWAAV LQSFVYKAGP
     451  WYNEPLGHNT PNHVHVCWQI PAYVLISFSE IFASITGLEY AYSKAPASMK
     501  SFIMSIFLLT NAFGSAIGCA LSPVTVDPKF TWLFTGLAVA CFISGCLFWL
     551  CFRKYNDTEE EMNAMDYEEE DEFDLNPISA PKANDIEILE PMESLRSTTK
     601  Y*

external links for Ptr2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	TCDB
YGOB	DIP	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ptr2p

1)	Island MD, et al. (1991) Isolation and characterization of S. cerevisiae mutants deficient in amino acid-inducible peptide transport. Curr Genet 20(6):457-63
2)	Byrd C, et al. (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17(1):269-77
3)	Hauser M, et al. (2001) Multiplicity and regulation of genes encoding peptide transporters in Saccharomyces cerevisiae. Mol Membr Biol 18(1):105-12
4)	Perry JR, et al. (1994) Isolation and characterization of a Saccharomyces cerevisiae peptide transport gene. Mol Cell Biol 14(1):104-15