KTR2/YKR061W Protein Information

Standard Name	Ktr2p 1
Systematic Name	Ykr061wp
ORF Classification	Verified
Description	Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication (2, 3)
Name Description	Kre Two Related 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	425
Molecular Weight (Da)	50,651
Isoelectric Point (pI)	5.61

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ktr2p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012E11D \| P33550 MIPS: YKR061W NCBI: 311111 \| 398365275 \| 462469 \| 486525 \| NP_012987.3 \| NM_001179851.3 GenBank/EMBL/DDBJ: DAA09212.1 \| L17083 \| Z28286
External Classifications	EC: 2.4.1.- [Hexosyltransferases] EC: 2.4.1.131 [GDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase]

Amino Acid Sequence (or in FASTA format)
1 MQICKVFLTQ VKKLLFVSLL FCLIAQTCWL ALVPYQRQLS LDSYFFRRSR 51 EVSSRYDFTR RRHMNQTLKL SSNTYNDEPL NKTKGIKNQR ENATLLMLVR 101 NWELSGALRS MRSLEDRFNK NYQYDWTFLN DVPFDQEFIE ATTAMASGRT 151 QYALIPAEDW NRPSWINETL FEEALQLMEE KNILYGGSKS YRNMCRFNSG 201 FFFRQKILDP YDFYFRVEPD VEYFCDFPYD PFKVMRQNNK KYGFVITMYE 251 YEDTIPSLWE AVEEYLEETE SADIDMESNA FGFVSNFDFI GKSFGVIDSN 301 SGYNLCHFWT NFEIGDLNFF RSEKYIRFFE YLDSKGGFYY ERWGDAPVHS 351 IAASLLLKKD EIIHFDELGY KHMPFGTCPS AYYLRLQQRC LCDSNHPDNI 401 DLNVISCLRR WWKDGSGKYF LKHDS*

Amino Acid Sequence (or in FASTA format)

       1  MQICKVFLTQ VKKLLFVSLL FCLIAQTCWL ALVPYQRQLS LDSYFFRRSR
      51  EVSSRYDFTR RRHMNQTLKL SSNTYNDEPL NKTKGIKNQR ENATLLMLVR
     101  NWELSGALRS MRSLEDRFNK NYQYDWTFLN DVPFDQEFIE ATTAMASGRT
     151  QYALIPAEDW NRPSWINETL FEEALQLMEE KNILYGGSKS YRNMCRFNSG
     201  FFFRQKILDP YDFYFRVEPD VEYFCDFPYD PFKVMRQNNK KYGFVITMYE
     251  YEDTIPSLWE AVEEYLEETE SADIDMESNA FGFVSNFDFI GKSFGVIDSN
     301  SGYNLCHFWT NFEIGDLNFF RSEKYIRFFE YLDSKGGFYY ERWGDAPVHS
     351  IAASLLLKKD EIIHFDELGY KHMPFGTCPS AYYLRLQQRC LCDSNHPDNI
     401  DLNVISCLRR WWKDGSGKYF LKHDS*

external links for Ktr2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ktr2p

1)	Bussey, H. (1992) Personal Communication, Mortimer Map Edition 11
2)	Lussier M, et al. (1996) Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family. J Biol Chem 271(18):11001-8
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Lussier M, et al. (1997) Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism. Yeast 13(3):267-74