VPS51/YKR020W Protein Information Help

Standard Name Vps51p 1, 2
Systematic Name Ykr020wp
Alias Whi6p 3 , Api3p 4 , Vps67p 5
ORF Classification Verified
Description Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p (2, 6, 7)
Name Description Vacuolar Protein Sorting
Experimental Data
Molecules/cell 319 8
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 164
Molecular Weight (Da) 18,912
Isoelectric Point (pI) 4.72

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Vps51p (InterPro)
Physical Interactions There are 26 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052FA8 | P36116
MIPS: YKR020W
NCBI: 45271002 | 486441 | 549593 | 6322872 | 88192561 | 88192565 | NP_012945.1 | NM_001179810.1
GenBank/EMBL/DDBJ: DAA09175.1 | AY558556 | Z28245
Amino Acid Sequence (or in FASTA format)
 
       1  MAEQISHKKS LRVSSLNKDR RLLLREFYNL ENEPNKGRQE ARIGEKASEA
      51  HSGEEQVTDV NIDTEANTEK PVKDDELSAT EEDLKEGSED AEEEIKNLPF
     101  KRLVQIHNKL LGKETETNNS IKNTIYENYY DLIKVNDLLK EITNANEDQI
     151  NKLKQTVESL IKEL*

external links for Vps51p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome


DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Vps51p
1) Conibear E and Stevens TH  (2000) Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi. Mol Biol Cell 11(1):305-23
2) Siniossoglou S and Pelham HR  (2002) Vps51p links the VFT complex to the SNARE Tlg1p. J Biol Chem 277(50):48318-24
3) Jorgensen P, et al.  (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297(5580):395-400
4) Bidlingmaier S and Snyder M  (2002) Large-scale identification of genes important for apical growth in Saccharomyces cerevisiae by directed allele replacement technology (DART) screening. Funct Integr Genomics 1(6):345-56
5) Bonangelino CJ, et al.  (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501
6) Reggiori F, et al.  (2003) Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion. J Biol Chem 278(7):5009-20
7) Conibear E, et al.  (2003) Vps51p mediates the association of the GARP (Vps52/53/54) complex with the late Golgi t-SNARE Tlg1p. Mol Biol Cell 14(4):1610-23
8) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41