YPT52/YKR014C Protein Information

Standard Name	Ypt52p 1
Systematic Name	Ykr014cp
ORF Classification	Verified
Description	Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5)
Name Description	Yeast Protein Two 1

Experimental Data
Molecules/cell	9380 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	234
Molecular Weight (Da)	26,132
Isoelectric Point (pI)	4.52

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ypt52p (InterPro)
Physical Interactions	There are 60 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052FA1 \| P36018 MIPS: YKR014C NCBI: 483599 \| 486429 \| 549796 \| 6322866 \| NP_012939.1 GenBank/EMBL/DDBJ: DAA09169.1 \| X76174 \| Z28239

Amino Acid Sequence (or in FASTA format)
1 MLQFKLVLLG DSSVGKSSIV HRFVKDTFDE LRESTIGAAF LSQSITIHPN 51 DGNETKDVVI KFEIWDTAGQ ERYKSLAPMY YRNANAALVV YDITQEDSLQ 101 KARNWVDELK NKVGDDDLVI YLLGNKVDLC QETPSTETSP DSNEGGDEEQ 151 KVRAISTEEA KQYAQEQGLL FREVSAKTGE GVKEIFQDIG EKLYDLKKDE 201 ILSKQNRQIG GGNNGQVDIN LQRPSTNDPT SCCS*

Amino Acid Sequence (or in FASTA format)

       1  MLQFKLVLLG DSSVGKSSIV HRFVKDTFDE LRESTIGAAF LSQSITIHPN
      51  DGNETKDVVI KFEIWDTAGQ ERYKSLAPMY YRNANAALVV YDITQEDSLQ
     101  KARNWVDELK NKVGDDDLVI YLLGNKVDLC QETPSTETSP DSNEGGDEEQ
     151  KVRAISTEEA KQYAQEQGLL FREVSAKTGE GVKEIFQDIG EKLYDLKKDE
     201  ILSKQNRQIG GGNNGQVDIN LQRPSTNDPT SCCS*

external links for Ypt52p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ypt52p

1)	Singer-Kruger B, et al. (1994) Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. J Cell Biol 125(2):283-98
2)	Lazar T, et al. (1997) Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell? Trends Biochem Sci 22(12):468-72
3)	Nickerson DP, et al. (2012) Termination of isoform-selective Vps21/Rab5 signaling at endolysosomal organelles by Msb3/Gyp3. Traffic 13(10):1411-28
4)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5)	Cabrera M, et al. (2013) Functional separation of endosomal fusion factors and the class C core vacuole/endosome tethering (CORVET) complex in endosome biogenesis. J Biol Chem 288(7):5166-75
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41