MCH2/YKL221W Protein Information

Standard Name	Mch2p 1
Systematic Name	Ykl221wp
ORF Classification	Verified
Description	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport (1)
Name Description	MonoCarboxylate transporter Homologue 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	473
Molecular Weight (Da)	52,257
Isoelectric Point (pI)	8.8

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mch2p (InterPro)
Transmembrane Domains	There are 11 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0001F7BD5E \| P36032 MIPS: YKL221W NCBI: 330443640 \| 347595674 \| 473128 \| 486397 \| 549759 \| NP_012701.2 GenBank/EMBL/DDBJ: DAA08948.2 \| X75950 \| Z28221

Amino Acid Sequence (or in FASTA format)
1 MSEERHEDHH RDVENKLNLN GKDDINGNTS ISIEVPDGGY GWFILLAFIL 51 YNFSTWGANS GYAIYLAHYL ENNTFAGGSK LDYASIGGLA FSCGLFFAPV 101 ITWLYHIFSI QFIIGLGILF QGAALLLAAF SVTLWEIYLT QGVLIGFGLA 151 FIFIPSVTLI PLWFRNKRSL ASGIGTAGSG LGGIVFNLGM QSILQKRGVK 201 WALIAQCIIC TSLSTIALML TRTTHQGLRQ HKRSYKFELL DYDVLSNFAV 251 WLLFGFVSFA MLGYVVLLYS LSDFTVSLGY TSKQGSYVSC MVSVGSLLGR 301 PIVGHIADKY GSLTVGMILH LVMAILCWAM WIPCKNLATA IAFGLLVGSI 351 MGTIWPTIAS IVTRIVGLQK LPGTFGSTWI FMAAFALVAP IIGLELRSTD 401 TNGNDYYRTA IFVGFAYFGV SLCQWLLRGF IIARDEIAVR EAYSADQNEL 451 HLNVKLSHMS KCLFRYKQLP RRV*

Amino Acid Sequence (or in FASTA format)

       1  MSEERHEDHH RDVENKLNLN GKDDINGNTS ISIEVPDGGY GWFILLAFIL
      51  YNFSTWGANS GYAIYLAHYL ENNTFAGGSK LDYASIGGLA FSCGLFFAPV
     101  ITWLYHIFSI QFIIGLGILF QGAALLLAAF SVTLWEIYLT QGVLIGFGLA
     151  FIFIPSVTLI PLWFRNKRSL ASGIGTAGSG LGGIVFNLGM QSILQKRGVK
     201  WALIAQCIIC TSLSTIALML TRTTHQGLRQ HKRSYKFELL DYDVLSNFAV
     251  WLLFGFVSFA MLGYVVLLYS LSDFTVSLGY TSKQGSYVSC MVSVGSLLGR
     301  PIVGHIADKY GSLTVGMILH LVMAILCWAM WIPCKNLATA IAFGLLVGSI
     351  MGTIWPTIAS IVTRIVGLQK LPGTFGSTWI FMAAFALVAP IIGLELRSTD
     401  TNGNDYYRTA IFVGFAYFGV SLCQWLLRGF IIARDEIAVR EAYSADQNEL
     451  HLNVKLSHMS KCLFRYKQLP RRV*

external links for Mch2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Mch2p

1)	Makuc J, et al. (2001) The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Yeast 18(12):1131-43