TOR2/YKL203C Protein Information 
| Standard Name | Tor2p 1 |
|---|---|
| Systematic Name | Ykl203cp |
| Alias | Drr2p 2 |
| ORF Classification | Verified |
| Description | PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication (10, 11, 12, 13, 3, 4, 5, 6, 7, 8, 9) |
| Name Description | Target Of Rapamycin 14, 15 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Tor2p (InterPro) |
| Physical Interactions | There are 132 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI0000155BB3 | P32600 MIPS: YKL203C NCBI: 122066477 | 298028 | 42759860 | 486361 | 549092 | NP_012719.2 | NM_001179768.1 GenBank/EMBL/DDBJ: DAA08966.1 | X71416 | Z28203 |
| External Classifications | EC: 2.7.1.67 [1-phosphatidylinositol 4-kinase] EC: 2.7.11.1 [Non-specific serine/threonine protein kinase] |
external links for Tor2p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| Candida (CGD) | BioPIXIE | MIPS | |
| YGOB | CYC2008 (complexes) | Pfam domains | |
| YOGY | Complexome | ||
| DIP | |||
| GeneMANIA |
References cited on this page View Complete Literature Guide for Tor2p
| 1) | Hall, M. (1993) Personal Communication, Mortimer Map Edition 12 |
| 2) | Cafferkey R, et al. (1993) Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol Cell Biol 13(10):6012-23 |
| 3) | Zheng XF and Schreiber SL (1997) Target of rapamycin proteins and their kinase activities are required for meiosis. Proc Natl Acad Sci U S A 94(7):3070-5 |
| 4) | Kamada Y, et al. (2000) Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 150(6):1507-13 |
| 5) | Schmidt A, et al. (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci U S A 93(24):13780-5 |
| 6) | Beck T and Hall MN (1999) The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402(6762):689-92 |
| 7) | Powers T and Walter P (1999) Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol Biol Cell 10(4):987-1000 |
| 8) | Cardenas ME, et al. (1999) The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev 13(24):3271-9 |
| 9) | Loewith R, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10(3):457-68 |
| 10) | Torres J, et al. (2002) Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast. J Biol Chem 277(45):43495-504 |
| 11) | Lorberg A and Hall MN (2004) TOR: the first 10 years. Curr Top Microbiol Immunol 279():1-18 |
| 12) | Martin DE, et al. (2004) TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell 119(7):969-79 |
| 13) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 14) | Kunz J, et al. (1993) Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73(3):585-96 |
| 15) | Heitman J, et al. (1991) Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253(5022):905-9 |
