PEX1/YKL197C Protein Information

Standard Name	Pex1p 1
Systematic Name	Ykl197cp
Alias	Pas1p 2
ORF Classification	Verified
Description	AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis (3, 4, 5, 6, 7)
Name Description	PEroXin 1

Experimental Data
Molecules/cell	2100 8

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,043
Molecular Weight (Da)	117,275
Isoelectric Point (pI)	6.93

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pex1p (InterPro)
Physical Interactions	There are 30 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001316D8 \| P24004 MIPS: YKL197C NCBI: 172098 \| 486351 \| 548458 \| 6322651 \| NP_012724.1 \| NM_001179763.1 GenBank/EMBL/DDBJ: DAA08969.1 \| M58676 \| Z28197

Amino Acid Sequence (or in FASTA format)
1 MTTTKRLKFE NLRIQFSNAI VGNFLRLPHS IINVLESTNY AIQEFGIAVH 51 SHNSDIPIVH LGWDGHDSGS SENVVLINPV LATVYDLNQK SPLVDLYIQR 101 YDHTHLATEV YVTPETSDDW EIIDANAMRF QNGEILHQTR IVTPGETLIC 151 YLEGIVTKFK IDRVEPSMKS ARITDGSLVV VAPKVNKTRL VKAEYGHSNK 201 TILKNGAIQL LKKVILRSTV CKMDFPKDNL FVVYISDGAQ LPSQKGYASI 251 VKCSLRQSKK SDSDNKSVGI PSKKIGVFIK CDSQIPENHI ALSSHLWDAF 301 FTHPMNGAKI KLEFLQMNQA NIISGRNATV NIKYFGKDVP TKSGDQYSKL 351 LGGSLLTNNL ILPTEQIIIE IKKGESEQQL CNLNEISNES VQWKVTQMGK 401 EEVKDIIERH LPKHYHVKET GEVSRTSKDE DDFITVNSIK KEMVNYLTSP 451 IIATPAIILD GKQGIGKTRL LKELINEVEK DHHIFVKYAD CETLHETSNL 501 DKTQKLIMEW CSFCYWYGPS LIVLDNVEAL FGKPQANDGD PSNNGQWDNA 551 SKLLNFFINQ VTKIFNKDNK RIRVLFSGKQ KTQINPLLFD KHFVSETWSL 601 RAPDKHARAK LLEYFFSKNQ IMKLNRDLQF SDLSLETEGF SPLDLEIFTE 651 KIFYDLQLER DCDNVVTREL FSKSLSAFTP SALRGVKLTK ETNIKWGDIG 701 ALANAKDVLL ETLEWPTKYE PIFVNCPLRL RSGILLYGYP GCGKTLLASA 751 VAQQCGLNFI SVKGPEILNK FIGASEQNIR ELFERAQSVK PCILFFDEFD 801 SIAPKRGHDS TGVTDRVVNQ LLTQMDGAEG LDGVYILAAT SRPDLIDSAL 851 LRPGRLDKSV ICNIPTESER LDILQAIVNS KDKDTGQKKF ALEKNADLKL 901 IAEKTAGFSG ADLQGLCYNA YLKSVHRWLS AADQSEVVPG NDNIEYFSIN 951 EHGRREENRL RLKTLLQQDV VHETKTSTSA ASELTAVVTI NDLLEACQET 1001 KPSISTSELV KLRGIYDRFQ KDRNGEMPNG ENSIDIGSRL SLM*

Amino Acid Sequence (or in FASTA format)

       1  MTTTKRLKFE NLRIQFSNAI VGNFLRLPHS IINVLESTNY AIQEFGIAVH
      51  SHNSDIPIVH LGWDGHDSGS SENVVLINPV LATVYDLNQK SPLVDLYIQR
     101  YDHTHLATEV YVTPETSDDW EIIDANAMRF QNGEILHQTR IVTPGETLIC
     151  YLEGIVTKFK IDRVEPSMKS ARITDGSLVV VAPKVNKTRL VKAEYGHSNK
     201  TILKNGAIQL LKKVILRSTV CKMDFPKDNL FVVYISDGAQ LPSQKGYASI
     251  VKCSLRQSKK SDSDNKSVGI PSKKIGVFIK CDSQIPENHI ALSSHLWDAF
     301  FTHPMNGAKI KLEFLQMNQA NIISGRNATV NIKYFGKDVP TKSGDQYSKL
     351  LGGSLLTNNL ILPTEQIIIE IKKGESEQQL CNLNEISNES VQWKVTQMGK
     401  EEVKDIIERH LPKHYHVKET GEVSRTSKDE DDFITVNSIK KEMVNYLTSP
     451  IIATPAIILD GKQGIGKTRL LKELINEVEK DHHIFVKYAD CETLHETSNL
     501  DKTQKLIMEW CSFCYWYGPS LIVLDNVEAL FGKPQANDGD PSNNGQWDNA
     551  SKLLNFFINQ VTKIFNKDNK RIRVLFSGKQ KTQINPLLFD KHFVSETWSL
     601  RAPDKHARAK LLEYFFSKNQ IMKLNRDLQF SDLSLETEGF SPLDLEIFTE
     651  KIFYDLQLER DCDNVVTREL FSKSLSAFTP SALRGVKLTK ETNIKWGDIG
     701  ALANAKDVLL ETLEWPTKYE PIFVNCPLRL RSGILLYGYP GCGKTLLASA
     751  VAQQCGLNFI SVKGPEILNK FIGASEQNIR ELFERAQSVK PCILFFDEFD
     801  SIAPKRGHDS TGVTDRVVNQ LLTQMDGAEG LDGVYILAAT SRPDLIDSAL
     851  LRPGRLDKSV ICNIPTESER LDILQAIVNS KDKDTGQKKF ALEKNADLKL
     901  IAEKTAGFSG ADLQGLCYNA YLKSVHRWLS AADQSEVVPG NDNIEYFSIN
     951  EHGRREENRL RLKTLLQQDV VHETKTSTSA ASELTAVVTI NDLLEACQET
    1001  KPSISTSELV KLRGIYDRFQ KDRNGEMPNG ENSIDIGSRL SLM*

external links for Pex1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Pex1p

1)	Distel B, et al. (1996) A unified nomenclature for peroxisome biogenesis factors. J Cell Biol 135(1):1-3
2)	Erdmann R, et al. (1989) Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 86(14):5419-23
3)	Krause T, et al. (1994) Effect of site-directed mutagenesis of conserved lysine residues upon Pas1 protein function in peroxisome biogenesis. Yeast 10(12):1613-20
4)	Erdmann R, et al. (1991) PAS1, a yeast gene required for peroxisome biogenesis, encodes a member of a novel family of putative ATPases. Cell 64(3):499-510
5)	Skoneczny M and Rytka J (2000) Oxygen and haem regulate the synthesis of peroxisomal proteins: catalase A, acyl-CoA oxidase and Pex1p in the yeast Saccharomyces cerevisiae; the regulation of these proteins by oxygen is not mediated by haem. Biochem J 350 Pt 1():313-9
6)	Birschmann I, et al. (2005) Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and Pex6p. FEBS J 272(1):47-58
7)	Platta HW, et al. (2005) Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol. Nat Cell Biol 7(8):817-22
8)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41