HYM1/YKL189W Protein Information

Standard Name	Hym1p 1
Systematic Name	Ykl189wp
ORF Classification	Verified
Description	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response (2)

Experimental Data
Molecules/cell	1280 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	399
Molecular Weight (Da)	45,853
Isoelectric Point (pI)	8.52

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hym1p (InterPro)
Physical Interactions	There are 17 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012D010 \| P32464 MIPS: YKL189W NCBI: 296989 \| 395236 \| 418609 \| 486335 \| 6322659 \| NP_012732.1 \| NM_001179755.1 GenBank/EMBL/DDBJ: DAA08977.1 \| X69765 \| X74151 \| Z28189

Amino Acid Sequence (or in FASTA format)
1 MFKKYKNQDL DMAFWWKKNP KTPSDYARLI IEQLNKFSSP SLTQDNKRKV 51 QEECTKYLIG TKHFIVGDTD PHPTPEAIDE LYTAMHRADV FYELLLHFVD 101 LEFEARRECM LIFSICLGYS KDNKFVTVDY LVSQPKTISL MLRTAEVALQ 151 QKGCQDIFLT VGNMIIECIK YEQLCRIILK DPQLWKFFEF AKLGNFEIST 201 ESLQILSAAF TAHPKLVSKE FFSNEINIIR FIKCINKLMA HGSYVTKRQS 251 TKLLASLIVI RSNNALMNIY INSPENLKLI MTLMTDKSKN LQLEAFNVFK 301 VMVANPRKSK PVFDILVKNR DKLLTYFKTF GLDSQDSTFL DEREFIVQEI 351 DSLPRIISST TEVSNNNASS SNVASITSPS SVMNNQSSIL THSTSPDSR*

Amino Acid Sequence (or in FASTA format)

       1  MFKKYKNQDL DMAFWWKKNP KTPSDYARLI IEQLNKFSSP SLTQDNKRKV
      51  QEECTKYLIG TKHFIVGDTD PHPTPEAIDE LYTAMHRADV FYELLLHFVD
     101  LEFEARRECM LIFSICLGYS KDNKFVTVDY LVSQPKTISL MLRTAEVALQ
     151  QKGCQDIFLT VGNMIIECIK YEQLCRIILK DPQLWKFFEF AKLGNFEIST
     201  ESLQILSAAF TAHPKLVSKE FFSNEINIIR FIKCINKLMA HGSYVTKRQS
     251  TKLLASLIVI RSNNALMNIY INSPENLKLI MTLMTDKSKN LQLEAFNVFK
     301  VMVANPRKSK PVFDILVKNR DKLLTYFKTF GLDSQDSTFL DEREFIVQEI
     351  DSLPRIISST TEVSNNNASS SNVASITSPS SVMNNQSSIL THSTSPDSR*

external links for Hym1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Hym1p

1)	Karos M and Fischer R (1999) Molecular characterization of HymA, an evolutionarily highly conserved and highly expressed protein of Aspergillus nidulans. Mol Gen Genet 260(6):510-21
2)	Nelson B, et al. (2003) RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol Biol Cell 14(9):3782-803
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41