PXA2/YKL188C Protein Information Help

Standard Name Pxa2p 1
Systematic Name Ykl188cp
Alias Pat1p
ORF Classification Verified
Description Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder (1, 2, 3, 4)
Name Description PeroXisomal ABC-transporter 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 853
Molecular Weight (Da) 97,125
Isoelectric Point (pI) 9.47

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pxa2p (InterPro)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 4 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000132BA8 | P34230
MIPS: YKL188C
NCBI: 1931633 | 395237 | 438237 | 465683 | 486333 | 6322660 | NP_012733.1 | NM_001179754.1
GenBank/EMBL/DDBJ: DAA08978.1 | U93584 | X74151 | X76133 | Z28188
External Classifications TC: 3.A.1.203 [The Peroxysomal Fatty Acyl CoA Transporter (P-FAT) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MISTASAFYQ KHRVNLLRSS YIILLLATLY NSNSSSSNNK TDKKDSESTV
      51  LENKKIEEGK ETAVDREEDE SSKEELTIVS KHSTDSEDGA IIIDKESKTN
     101  HKGGERKGKV DFLFKLLLHD KKCLILFITQ AILLNIRTLL SLRVATLDGQ
     151  LVSTLVRAQY ANFTKILLGK WMILGIPASF INSLISYTTK LCAVTINRKV
     201  SDFLLSKYLS NHHTFYSVAS AESVSEIQDN LTKDIYTFSM NSSLLLNQLL
     251  KPMLDLILCS FKLLTSNTSV MGEGTLALGL IVYASNSLLK LIQPNFTRLT
     301  MASASLESWF RSLHSNLHSS NEEIALLRGQ KRELENVDYS FYRLVLFLNR
     351  EIKARAIYDV ATAFVIKYTW GAAGLVLCSI PIFFKNKPSE DTLQLKEPGN
     401  DMTADFITNR RLLVTASSSI GRFVELKRNI QQLRGIRLRL NKFNDLLDAN
     451  KGDDEKEPRD ERCIVEYDDS RIKFENIPLI TPANQVLVPE LSFDLKHGNH
     501  LLIIGPNGCG KSSLFRILGG LWPIRATPNK NHQSKLIMPR RTVDRDCAIF
     551  YLPQRPYMGN RSTFREQIIY PDSIEQFKER YHNDYDLGDA DLIKILQLLD
     601  LEDLVTENMS LLLAQRTSKN DSQQLSTEDN QSPCAIKVRD AFSIVRNWSE
     651  ELTIGVQQRL AMARMYYHKP KFAVLDECTS AVAPEMEQRM YENAQNFGIS
     701  LISVCHRTSL WHFHNYLLKF DGKGGYQFGP FNPKERLCNE EKLLELNAIL
     751  DQQVPLWERK LKDLTIAKES NIIRKSETNL NLFEKIEDPK TSKSNALFNA
     801  NKGQRITSPT GQETSKRLPL FSQPSSSASS NLLRNNKSLN KKVKTKKEEG
     851  KER*

external links for Pxa2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome TCDB
YGOB DIP YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Pxa2p
1) Shani N and Valle D  (1996) A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters. Proc Natl Acad Sci U S A 93(21):11901-6
2) Verleur N, et al.  (1997) Transport of activated fatty acids by the peroxisomal ATP-binding-cassette transporter Pxa2 in a semi-intact yeast cell system. Eur J Biochem 249(3):657-61
3) Shani N, et al.  (1996) An S. cerevisiae peroxisomal transporter, orthologous to the human adrenoleukodystrophy protein, appears to be a heterodimer of two half ABC transporters: Pxa1p and Pxa2p. Ann N Y Acad Sci 804:770-2
4) Hettema EH, et al.  (1996) The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae. EMBO J 15(15):3813-22