TPO5/YKL174C Protein Information

Standard Name	Tpo5p 1
Systematic Name	Ykl174cp
ORF Classification	Verified
Description	Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles (1)
Name Description	Transporter of POlyamines 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	618
Molecular Weight (Da)	69,242
Isoelectric Point (pI)	5.11

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tpo5p (InterPro)
Transmembrane Domains	There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B753 \| P36029 MIPS: YKL174C NCBI: 407507 \| 486306 \| 549738 \| 6322674 \| NP_012747.1 GenBank/EMBL/DDBJ: DAA08992.1 \| Z26878 \| Z28174
External Classifications	TC: 2.A.3.4 [The Amino Acid/Choline Transporter (ACT) Family]

Amino Acid Sequence (or in FASTA format)
1 MPEYTLLADN IRENIVHFDP NGLFDNLHTI VHEDDSQENE EAEHFNYDQV 51 LDKSLLSRGS IVGLGLGLMS PVLGMCTSMA IGLINGGPLT IMLGFLISGV 101 CIWFSSLSLG EIVSKFPMEL HVGSAMLAPE KLKLVCSWYT GWLMLIGNWT 151 MSTSITFAGA QLTISLILMT NSNLISEAHL IFYTVIVFYL VVTVVGLVNL 201 KFARFIETIN KVCVYWIIYA IIFIDILLLV FHKGKFRSLK YALFHFDNNL 251 SGYKSAFLSF IIGFQQSNFT LQGFSMLPAL ADEVKVPEKD IPRGMSNAVL 301 LSAFSGVIFL IPIMLILPDN DLLFTNHKVL PIVNIFTKST DSVVLSFFLV 351 LLILGNLLFS GIGSITTSSR AVYSFSRDQA IPYYDKWTYV EPDSQSKVPK 401 NSVVLSMIIS YFLGLLALIS TAAFNAFIGA AVLCLCSATF IPLVLVLFTR 451 RRAIRSAPVK IRYKFGWFIN IVSIVWLLLS MVSVCLPTQV PVTFKTMNYA 501 LMVYVFCILV ITGLYFKWGK YNFRLPLADD IKAPIPSDAE ETVFELEDSN 551 VEHTLNSGTT VKESVENNSE EGFIKVHPKS STENPFEENE ENVITDYGDE 601 HHTAEQEFDL ADDRRYDI*

Amino Acid Sequence (or in FASTA format)

       1  MPEYTLLADN IRENIVHFDP NGLFDNLHTI VHEDDSQENE EAEHFNYDQV
      51  LDKSLLSRGS IVGLGLGLMS PVLGMCTSMA IGLINGGPLT IMLGFLISGV
     101  CIWFSSLSLG EIVSKFPMEL HVGSAMLAPE KLKLVCSWYT GWLMLIGNWT
     151  MSTSITFAGA QLTISLILMT NSNLISEAHL IFYTVIVFYL VVTVVGLVNL
     201  KFARFIETIN KVCVYWIIYA IIFIDILLLV FHKGKFRSLK YALFHFDNNL
     251  SGYKSAFLSF IIGFQQSNFT LQGFSMLPAL ADEVKVPEKD IPRGMSNAVL
     301  LSAFSGVIFL IPIMLILPDN DLLFTNHKVL PIVNIFTKST DSVVLSFFLV
     351  LLILGNLLFS GIGSITTSSR AVYSFSRDQA IPYYDKWTYV EPDSQSKVPK
     401  NSVVLSMIIS YFLGLLALIS TAAFNAFIGA AVLCLCSATF IPLVLVLFTR
     451  RRAIRSAPVK IRYKFGWFIN IVSIVWLLLS MVSVCLPTQV PVTFKTMNYA
     501  LMVYVFCILV ITGLYFKWGK YNFRLPLADD IKAPIPSDAE ETVFELEDSN
     551  VEHTLNSGTT VKESVENNSE EGFIKVHPKS STENPFEENE ENVITDYGDE
     601  HHTAEQEFDL ADDRRYDI*

external links for Tpo5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	TCDB
YGOB	DIP	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Tpo5p

1)	Tachihara K, et al. (2005) Excretion of putrescine and spermidine by the protein encoded by YKL174c (TPO5) in Saccharomyces cerevisiae. J Biol Chem 280(13):12637-42
2)	Tomitori H, et al. (1999) Identification of a gene for a polyamine transport protein in yeast. J Biol Chem 274(6):3265-7