KKQ8/YKL168C Protein Information

Standard Name	Kkq8p
Systematic Name	Ykl168cp
ORF Classification	Verified
Description	Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication (1, 2)

Experimental Data
Molecules/cell	981 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	724
Molecular Weight (Da)	82,589
Isoelectric Point (pI)	9.09

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Kkq8p (InterPro)
Physical Interactions	There are 38 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000D796A0 \| P36004 MIPS: YKL168C NCBI: 189047112 \| 407514 \| 486295 \| 547784 \| 99030927 \| NP_012753.2 GenBank/EMBL/DDBJ: DAA08997.1 \| Z26878 \| Z28168
External Classifications	EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MVMQEEKKRQ QPVTRRVRSF SESFKNLFRP PRSRDSSPIN VTRIPYRSSS 51 TSPKRSSEPP RRSTVSAQIL DPKNSPIRQR SYTLKCCTPG LSHPFRQTGS 101 GASNSPTRHR SISGEEQEIV NSLPEYKRSA SHTFHGIRRP RSRSSSVSSC 151 DSSNGTTSSS DSQWAMDSLL DDSDNDLTPY RGSNKDILKS KDRAPYNYID 201 DYNKKALRRA TSYPNPLPSK QFYNERLYTR RSHPDEESLE SLPRFAGADV 251 QCIIEQNGFK VYEDGSHEHN IKLSGVIAKL EKGNSLPAHR QGSLSRPRLG 301 ITLSGLFKHH KNECDIENAL SLLPNVEKSQ TNHEKRTGQS PNDSNRSSPT 351 QGREDYLKIV NPDASLGSDE LKLINSLSSR IHKSLQNYLQ EKNLKPAECI 401 GEQAPTFQDN YGHPVGLVGA GAYGEVKLCA RLRNEKDSPP FETYHDSKYI 451 YYAVKELKPK PDSDLEKFCT KITSEFIIGH SLSHYHKNGK KPAPNILNVF 501 DILEDSSSFI EVMEFCPAGD LYGMLVGKSK LKGRLHPLEA DCFMKQLLHG 551 VKFMHDHGIA HCDLKPENIL FYPHGLLKIC DFGTSSVFQT AWERRVHAQK 601 GIIGSEPYVA PEEFVDGEYY DPRLIDCWSC GVVYITMILG HYLWKVASRE 651 KDMSYDEFYK EMQRKNQFRV FEELKHVNSE LATNRKIALY RIFQWEPRKR 701 ISVGKLLDMQ WMKSTNCCLI YDST*

Amino Acid Sequence (or in FASTA format)

       1  MVMQEEKKRQ QPVTRRVRSF SESFKNLFRP PRSRDSSPIN VTRIPYRSSS
      51  TSPKRSSEPP RRSTVSAQIL DPKNSPIRQR SYTLKCCTPG LSHPFRQTGS
     101  GASNSPTRHR SISGEEQEIV NSLPEYKRSA SHTFHGIRRP RSRSSSVSSC
     151  DSSNGTTSSS DSQWAMDSLL DDSDNDLTPY RGSNKDILKS KDRAPYNYID
     201  DYNKKALRRA TSYPNPLPSK QFYNERLYTR RSHPDEESLE SLPRFAGADV
     251  QCIIEQNGFK VYEDGSHEHN IKLSGVIAKL EKGNSLPAHR QGSLSRPRLG
     301  ITLSGLFKHH KNECDIENAL SLLPNVEKSQ TNHEKRTGQS PNDSNRSSPT
     351  QGREDYLKIV NPDASLGSDE LKLINSLSSR IHKSLQNYLQ EKNLKPAECI
     401  GEQAPTFQDN YGHPVGLVGA GAYGEVKLCA RLRNEKDSPP FETYHDSKYI
     451  YYAVKELKPK PDSDLEKFCT KITSEFIIGH SLSHYHKNGK KPAPNILNVF
     501  DILEDSSSFI EVMEFCPAGD LYGMLVGKSK LKGRLHPLEA DCFMKQLLHG
     551  VKFMHDHGIA HCDLKPENIL FYPHGLLKIC DFGTSSVFQT AWERRVHAQK
     601  GIIGSEPYVA PEEFVDGEYY DPRLIDCWSC GVVYITMILG HYLWKVASRE
     651  KDMSYDEFYK EMQRKNQFRV FEELKHVNSE LATNRKIALY RIFQWEPRKR
     701  ISVGKLLDMQ WMKSTNCCLI YDST*

external links for Kkq8p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Kkq8p

1)	Hunter T and Plowman GD (1997) The protein kinases of budding yeast: six score and more. Trends Biochem Sci 22(1):18-22
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41