KDX1/YKL161C Protein Information

Standard Name	Kdx1p 1
Systematic Name	Ykl161cp
Alias	Mlp1p 2
ORF Classification	Verified
Description	Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication (1, 2, 3)
Name Description	Kinase Dead X-talker 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	433
Molecular Weight (Da)	49,632
Isoelectric Point (pI)	6.27

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Kdx1p (InterPro)
Physical Interactions	There are 31 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012DEC2 \| P36005 MIPS: YKL161C NCBI: 407487 \| 486281 \| 547783 \| 6322688 \| NP_012761.1 GenBank/EMBL/DDBJ: DAA09004.1 \| Z26877 \| Z28161
External Classifications	EC: 2.7.1.- [Phosphotransferases with an alcohol group as acceptor]

Amino Acid Sequence (or in FASTA format)
1 MATDTERCIF RAFGQDFILN KHFHLTGKIG RGSHSLICSS TYTESNEETH 51 VAIRKIPNAF GNKLSCKRTL RELKLLRHLR GHPNIVWLFD TDIVFYPNGA 101 LNGVYLYEEL MECDLSQIIR SEQRLEDAHF QSFIYQILCA LKYIHSANVL 151 HCDLKPKNLL VNSDCQLKIC NFGLSCSYSE NHKVNDGFIK GYITSIWYKA 201 PEILLNYQEC TKAVDIWSTG CILAELLGRK PMFEGKDYVD HLNHILQILG 251 TPPEETLQEI ASQKVYNYIF QFGNIPGRSF ESILPGANPE ALELLKKMLE 301 FDPKKRITVE DALEHPYLSM WHDIDEEFSC QKTFRFEFEH IESMAELGNE 351 VIKEVFDFRK VVRKHPISGD SPSSSLSLED AIPQEVVQVH PSRKVLPSYS 401 PEFSYVSQLP SLTTTQPYQN LMGISSNSFQ GVN*

Amino Acid Sequence (or in FASTA format)

       1  MATDTERCIF RAFGQDFILN KHFHLTGKIG RGSHSLICSS TYTESNEETH
      51  VAIRKIPNAF GNKLSCKRTL RELKLLRHLR GHPNIVWLFD TDIVFYPNGA
     101  LNGVYLYEEL MECDLSQIIR SEQRLEDAHF QSFIYQILCA LKYIHSANVL
     151  HCDLKPKNLL VNSDCQLKIC NFGLSCSYSE NHKVNDGFIK GYITSIWYKA
     201  PEILLNYQEC TKAVDIWSTG CILAELLGRK PMFEGKDYVD HLNHILQILG
     251  TPPEETLQEI ASQKVYNYIF QFGNIPGRSF ESILPGANPE ALELLKKMLE
     301  FDPKKRITVE DALEHPYLSM WHDIDEEFSC QKTFRFEFEH IESMAELGNE
     351  VIKEVFDFRK VVRKHPISGD SPSSSLSLED AIPQEVVQVH PSRKVLPSYS
     401  PEFSYVSQLP SLTTTQPYQN LMGISSNSFQ GVN*

external links for Kdx1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Kdx1p

1)	Breitkreutz A, et al. (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328(5981):1043-6
2)	Watanabe Y, et al. (1997) Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol 17(5):2615-23
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61