DBR1/YKL149C Protein Information

Standard Name	Dbr1p 1
Systematic Name	Ykl149cp
Alias	Prp26p 2
ORF Classification	Verified
Description	RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition (1)
Name Description	DeBRanching 1

Experimental Data
Molecules/cell	1130 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	405
Molecular Weight (Da)	47,741
Isoelectric Point (pI)	7.89

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Dbr1p (InterPro)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000128F34 \| P24309 MIPS: YKL149C NCBI: 118288 \| 171382 \| 172552 \| 172555 \| 407498 \| 486256 \| 6322700 \| NP_012773.1 GenBank/EMBL/DDBJ: DAA09014.1 \| M62813 \| M86909 \| M94874 \| Z26877 \| Z28149
External Classifications	EC: 3.1.-.- [Hydrolases acting on ester bonds ]

Amino Acid Sequence (or in FASTA format)
1 MTKLRIAVQG CCHGQLNQIY KEVSRIHAKT PIDLLIILGD FQSIRDGQDF 51 KSIAIPPKYQ RLGDFISYYN NEIEAPVPTI FIGGNHESMR HLMLLPHGGY 101 VAKNIFYMGY SNVIWFKGIR IGSLSGIWKE WDFNKQRPDW NDLENNNWKA 151 NIRNLYHVRI SDIAPLFMIK HRIDIMLSHD WPNGVVYHGD TKHLLKLKPF 201 FEQDIKEGKL GSPVTWQLLR DLRPQWWLSA HLHVRFMASI KHNKRSHEPP 251 NKSTSKTKKN NNEIDLDLSS DEDERSGIMN CQEENEYDSK YGETRFLALD 301 KCLPRRRWLE ILEIEPDTSH ASWKDENHRM FWDPEFINNL VICQKNKNLL 351 SNKPFNSVNW IELSQSNREE GRDIDWENYA IPAYTLDIQK DEVRQTKAFI 401 SKFMT*

Amino Acid Sequence (or in FASTA format)

       1  MTKLRIAVQG CCHGQLNQIY KEVSRIHAKT PIDLLIILGD FQSIRDGQDF
      51  KSIAIPPKYQ RLGDFISYYN NEIEAPVPTI FIGGNHESMR HLMLLPHGGY
     101  VAKNIFYMGY SNVIWFKGIR IGSLSGIWKE WDFNKQRPDW NDLENNNWKA
     151  NIRNLYHVRI SDIAPLFMIK HRIDIMLSHD WPNGVVYHGD TKHLLKLKPF
     201  FEQDIKEGKL GSPVTWQLLR DLRPQWWLSA HLHVRFMASI KHNKRSHEPP
     251  NKSTSKTKKN NNEIDLDLSS DEDERSGIMN CQEENEYDSK YGETRFLALD
     301  KCLPRRRWLE ILEIEPDTSH ASWKDENHRM FWDPEFINNL VICQKNKNLL
     351  SNKPFNSVNW IELSQSNREE GRDIDWENYA IPAYTLDIQK DEVRQTKAFI
     401  SKFMT*

external links for Dbr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Dbr1p

1)	Chapman KB and Boeke JD (1991) Isolation and characterization of the gene encoding yeast debranching enzyme. Cell 65(3):483-92
2)	Vijayraghavan U, et al. (1989) Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae. Genes Dev 3(8):1206-16
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41