PGM1/YKL127W Protein Information

Standard Name	Pgm1p 1
Systematic Name	Ykl127wp
ORF Classification	Verified
Description	Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; PGM1 has a paralog, PGM2, that arose from the whole genome duplication (1, 2)
Name Description	PhosphoGlucoMutase 3

Experimental Data
Molecules/cell	9820 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	570
Molecular Weight (Da)	63,111
Isoelectric Point (pI)	7.23

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pgm1p (InterPro)
Physical Interactions	There are 13 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000131852 \| P33401 MIPS: YKL127W NCBI: 397624 \| 464368 \| 486215 \| 6322722 \| NP_012795.1 GenBank/EMBL/DDBJ: DAA09034.1 \| X72016 \| Z28127
External Classifications	EC: 5.4.2.2 [Phosphoglucomutase]

Amino Acid Sequence (or in FASTA format)
1 MSLLIDSVPT VAYKDQKPGT SGLRKKTKVF MDEPHYTENF IQATMQSIPN 51 GSEGTTLVVG GDGRFYNDVI MNKIAAVGAA NGVRKLVIGQ GGLLSTPAAS 101 HIIRTYEEKC TGGGIILTAS HNPGGPENDL GIKYNLPNGG PAPESVTNAI 151 WEASKKLTHY KIIKNFPKLN LNKLGKNQKY GPLLVDIIDP AKAYVQFLKE 201 IFDFDLIKSF LAKQRKDKGW KLLFDSLNGI TGPYGKAIFV DEFGLPAEEV 251 LQNWHPLPDF GGLHPDPNLT YARTLVDRVD REKIAFGAAS DGDGDRNMIY 301 GYGPAFVSPG DSVAIIAEYA PEIPYFAKQG IYGLARSFPT SSAIDRVAAK 351 KGLRCYEVPT GWKFFCALFD AKKLSICGEE SFGTGSNHIR EKDGLWAIIA 401 WLNILAIYHR RNPEKEASIK TIQDEFWNEY GRTFFTRYDY EHIECEQAEK 451 VVALLSEFVS RPNVCGSHFP ADESLTVIDC GDFSYRDLDG SISENQGLFV 501 KFSNGTKFVL RLSGTGSSGA TIRLYVEKYT DKKENYGQTA DVFLKPVINS 551 IVKFLRFKEI LGTDEPTVRT *

Amino Acid Sequence (or in FASTA format)

       1  MSLLIDSVPT VAYKDQKPGT SGLRKKTKVF MDEPHYTENF IQATMQSIPN
      51  GSEGTTLVVG GDGRFYNDVI MNKIAAVGAA NGVRKLVIGQ GGLLSTPAAS
     101  HIIRTYEEKC TGGGIILTAS HNPGGPENDL GIKYNLPNGG PAPESVTNAI
     151  WEASKKLTHY KIIKNFPKLN LNKLGKNQKY GPLLVDIIDP AKAYVQFLKE
     201  IFDFDLIKSF LAKQRKDKGW KLLFDSLNGI TGPYGKAIFV DEFGLPAEEV
     251  LQNWHPLPDF GGLHPDPNLT YARTLVDRVD REKIAFGAAS DGDGDRNMIY
     301  GYGPAFVSPG DSVAIIAEYA PEIPYFAKQG IYGLARSFPT SSAIDRVAAK
     351  KGLRCYEVPT GWKFFCALFD AKKLSICGEE SFGTGSNHIR EKDGLWAIIA
     401  WLNILAIYHR RNPEKEASIK TIQDEFWNEY GRTFFTRYDY EHIECEQAEK
     451  VVALLSEFVS RPNVCGSHFP ADESLTVIDC GDFSYRDLDG SISENQGLFV
     501  KFSNGTKFVL RLSGTGSSGA TIRLYVEKYT DKKENYGQTA DVFLKPVINS
     551  IVKFLRFKEI LGTDEPTVRT *

external links for Pgm1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Pgm1p

1)	Boles E, et al. (1994) A family of hexosephosphate mutases in Saccharomyces cerevisiae. Eur J Biochem 220(1):83-96
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Bevan P and Douglas HC (1969) Genetic control of phosphoglucomutase variants in Saccharomyces cerevisiae. J Bacteriol 98(2):532-5
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41