DGR2/YKL121W Protein Information Help

Standard Name Dgr2p 1
Systematic Name Ykl121wp
ORF Classification Uncharacterized
Description Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds; DGR2 has a paralog, YMR102C, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description 2-Deoxy-Glucose Resistant 2 1
Experimental Data
Molecules/cell 504 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 852
Molecular Weight (Da) 96,021
Isoelectric Point (pI) 8.37

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Dgr2p (InterPro)
Physical Interactions There are 11 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B725 | P32330
MIPS: YKL121W
NCBI: 418567 | 486204 | 6322728 | 7580479 | NP_012801.1
GenBank/EMBL/DDBJ: DAA09039.1 | S44213 | Z28121
Amino Acid Sequence (or in FASTA format)
 
       1  MFKSKTSTLS YDETPNSNEG DRNATPVNPK EKSQTKHLNI PGDRSRHSSI
      51  ADSKRSSSRY DGGYSADIIP AQLRFIDNID YGTRLRKTLH RNSVVSNGYN
     101  KLSENDRWYF DLFDRKYFEN YLEEPTYIKI FKKKEGLEQF DRMFLAQELK
     151  IPDVYKSTTY QGEPAVANSE LFKNSICCCT FSHDGKYMVI GCKDGSLHLW
     201  KVINSPVKRS EMGRSEKSVS ASRANSLKIQ RHLASISSHN GSISSNDLKP
     251  SDQFEGPSKQ LHLYAPVFYS DVFRVFMEHA LDILDANWSK NGFLITASMD
     301  KTAKLWHPER KYSLKTFVHP DFVTSAIFFP NDDRFIITGC LDHRCRLWSI
     351  LDNEVSYAFD CKDLITSLTL SPPGGEYTII GTFNGYIYVL LTHGLKFVSS
     401  FHVSDKSTQG TTKNSFHPSS EYGKVQHGPR ITGLQCFFSK VDKNLRLIVT
     451  TNDSKIQIFD LNEKKPLELF KGFQSGSSRH RGQFLMMKNE PVVFTGSDDH
     501  WFYTWKMQSF NLSAEMNCTA PHRKKRLSGS MSLKGLLRIV SNKSTNDECL
     551  TETSNQSSSH TFTNSSKNVL QTQTVGSQAI KNNHYISFHA HNSPVTCASI
     601  APDVAIKNLS LSNDLIFELT SQYFKEMGQN YSESKETCDN KPNHPVTETG
     651  GFSSNLSNVV NNVGTILITT DSQGLIRVFR TDILPEIRKK IIEKFHEYNL
     701  FHLEAAGKIN NHNNDSILEN RMDERSSTED NEFSTTPPSN THNSRPSHDF
     751  CELHPNNSPV ISGMPSRASA IFKNSIFNKS NGSFISLKSR SESTSSTVFG
     801  PHDIPRVSTT YPKLKCDVCN GSNFECASKN PIAGGDSGFT CADCGTILNN
     851  FR*

external links for Dgr2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Dgr2p
1) Ralser M, et al.  (2008) A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth. Proc Natl Acad Sci U S A 105(46):17807-17811
2) Colleaux L, et al.  (1992) Sequence of a segment of yeast chromosome XI identifies a new mitochondrial carrier, a new member of the G protein family, and a protein with the PAAKK motif of the H1 histones. Yeast 8(4):325-36
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Watanabe M, et al.  (2009) Comprehensive and quantitative analysis of yeast deletion mutants defective in apical and isotropic bud growth. Curr Genet 55(4):365-80
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41