SBA1/YKL117W Protein Information

Standard Name	Sba1p 1
Systematic Name	Ykl117wp
ORF Classification	Verified
Description	Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description	increased Sensitivity to Benzoquinone Ansamycins 1

Experimental Data
Molecules/cell	33700 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	216
Molecular Weight (Da)	24,082
Isoelectric Point (pI)	4.29

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sba1p (InterPro)
Physical Interactions	There are 198 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004F939 \| P28707 MIPS: YKL117W NCBI: 1353070 \| 248394 \| 486197 \| 6322732 \| 99031947 \| 99031948 \| NP_012805.1 GenBank/EMBL/DDBJ: DAA09042.1 \| S93804 \| Z28117

Amino Acid Sequence (or in FASTA format)
1 MSDKVINPQV AWAQRSSTTD PERNYVLITV SIADCDAPEL TIKPSYIELK 51 AQSKPHVGDE NVHHYQLHID LYKEIIPEKT MHKVANGQHY FLKLYKKDLE 101 SEYWPRLTKE KVKYPYIKTD FDKWVDEDEQ DEVEAEGNDA AQGMDFSQMM 151 GGAGGAGGAG GMDFSQMMGG AGGAGSPDMA QLQQLLAQSG GNLDMGDFKE 201 NDEEDEEEEI EPEVKA*

Amino Acid Sequence (or in FASTA format)

       1  MSDKVINPQV AWAQRSSTTD PERNYVLITV SIADCDAPEL TIKPSYIELK
      51  AQSKPHVGDE NVHHYQLHID LYKEIIPEKT MHKVANGQHY FLKLYKKDLE
     101  SEYWPRLTKE KVKYPYIKTD FDKWVDEDEQ DEVEAEGNDA AQGMDFSQMM
     151  GGAGGAGGAG GMDFSQMMGG AGGAGSPDMA QLQQLLAQSG GNLDMGDFKE
     201  NDEEDEEEEI EPEVKA*

external links for Sba1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Sba1p

1)	Bohen SP (1998) Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins. Mol Cell Biol 18(6):3330-9
2)	Fang Y, et al. (1998) SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins. Mol Cell Biol 18(7):3727-34
3)	Toogun OA, et al. (2007) The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Proc Natl Acad Sci U S A 104(14):5765-70
4)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41