PRR1/YKL116C Protein Information

Standard Name	Prr1p
Systematic Name	Ykl116cp
ORF Classification	Verified
Description	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor (1, 2)
Name Description	Pheromone Response Regulator 1

Experimental Data
Molecules/cell	1510 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	518
Molecular Weight (Da)	58,955
Isoelectric Point (pI)	5.8

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Prr1p (InterPro)
Physical Interactions	There are 41 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012DEC1 \| P28708 MIPS: YKL116C NCBI: 140965 \| 248393 \| 486194 \| 6322733 \| NP_012806.1 GenBank/EMBL/DDBJ: DAA09043.1 \| S93804 \| Z28115
External Classifications	EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MDEYSSIYSQ PKTPRLKQEG FPDSIGDQHE KALIDENGEE DKKMASTEGT 51 TGDSRSTPLT VSIPTFENVQ ALPTPMTYTP LSPGNLSMSP IDQSSLNIPK 101 RRSHARLLDD MLSVTQPNQR VVSELIAPAN LSPQRVVSLP TVTEEALVND 151 SVDSDNYTKE PYFPESSSST EKCDDDIFQG FLLDHWDRPL LWKKVRPIGS 201 GNFSTVLLYE LMDQSNPKLK QVAVKRLKYP EELSNVEQIN TSLRYKETLS 251 RLENSLTREL QVLKSLNHPC IVKLLGINNP IFVTSKKPLC DLIIKTPRAL 301 PPCDMIMSYC PAGDLLAAVM ARNGRLEAWL IQRIFTEVVL AVKYLHENSI 351 IHRDLKLENI LLKYSFDDIN SFRDSPIYCK QNFIELADFG LCKKIENNEM 401 CTARCGSEDY VSPEILMGVP YDGHLSDTWA LGVILYSLFE DRLPFDPPPN 451 ASARQRSRAT SHRIARFDWR WYRLSDYKTN VGKQIVENTL TRKNQRWSIN 501 EIYESPFVKT IADTLSFS*

Amino Acid Sequence (or in FASTA format)

       1  MDEYSSIYSQ PKTPRLKQEG FPDSIGDQHE KALIDENGEE DKKMASTEGT
      51  TGDSRSTPLT VSIPTFENVQ ALPTPMTYTP LSPGNLSMSP IDQSSLNIPK
     101  RRSHARLLDD MLSVTQPNQR VVSELIAPAN LSPQRVVSLP TVTEEALVND
     151  SVDSDNYTKE PYFPESSSST EKCDDDIFQG FLLDHWDRPL LWKKVRPIGS
     201  GNFSTVLLYE LMDQSNPKLK QVAVKRLKYP EELSNVEQIN TSLRYKETLS
     251  RLENSLTREL QVLKSLNHPC IVKLLGINNP IFVTSKKPLC DLIIKTPRAL
     301  PPCDMIMSYC PAGDLLAAVM ARNGRLEAWL IQRIFTEVVL AVKYLHENSI
     351  IHRDLKLENI LLKYSFDDIN SFRDSPIYCK QNFIELADFG LCKKIENNEM
     401  CTARCGSEDY VSPEILMGVP YDGHLSDTWA LGVILYSLFE DRLPFDPPPN
     451  ASARQRSRAT SHRIARFDWR WYRLSDYKTN VGKQIVENTL TRKNQRWSIN
     501  EIYESPFVKT IADTLSFS*

external links for Prr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Prr1p

1)	Burchett SA, et al. (2001) Identification of novel pheromone-response regulators through systematic overexpression of 120 protein kinases in yeast. J Biol Chem 276(28):26472-8
2)	Zhu H, et al. (2000) Analysis of yeast protein kinases using protein chips. Nat Genet 26(3):283-9
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41