HSL1/YKL101W Protein Information Help

Standard Name Hsl1p
Systematic Name Ykl101wp
Alias Nik1p , Elm2p 1
ORF Classification Verified
Description Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p (2, 3, 4, 5, 6)
Name Description Histone Synthetic Lethal 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,518
Molecular Weight (Da) 169,606
Isoelectric Point (pI) 9.93

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hsl1p (InterPro)
Physical Interactions There are 152 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000158EEB1 | P34244
MIPS: YKL101W
NCBI: 1519247 | 330443652 | 347595660 | 431215 | 462451 | 486169 | NP_012821.2
GenBank/EMBL/DDBJ: DAA09056.2 | U65921 | X71133 | Z28101
External Classifications EC: 2.7.11.- [Protein-serine/threonine kinases]
Amino Acid Sequence (or in FASTA format)
 
       1  MTGHVSKTSH VPKGRPSSLA KKAAKRAMAK VNSNPKRASG HLERVVQSVN
      51  DATKRLSQPD STVSVATKSS KRKSRDTVGP WKLGKTLGKG SSGRVRLAKN
     101  METGQLAAIK IVPKKKAFVH CSNNGTVPNS YSSSMVTSNV SSPSIASREH
     151  SNHSQTNPYG IEREIVIMKL ISHTNVMALF EVWENKSELY LVLEYVDGGE
     201  LFDYLVSKGK LPEREAIHYF KQIVEGVSYC HSFNICHRDL KPENLLLDKK
     251  NRRIKIADFG MAALELPNKL LKTSCGSPHY ASPEIVMGRP YHGGPSDVWS
     301  CGIVLFALLT GHLPFNDDNI KKLLLKVQSG KYQMPSNLSS EARDLISKIL
     351  VIDPEKRITT QEILKHPLIK KYDDLPVNKV LRKMRKDNMA RGKSNSDLHL
     401  LNNVSPSIVT LHSKGEIDES ILRSLQILWH GVSRELITAK LLQKPMSEEK
     451  LFYSLLLQYK QRHSISLSSS SENKKSATES SVNEPRIEYA SKTANNTGLR
     501  SENNDVKTLH SLEIHSEDTS TVNQNNAITG VNTEINAPVL AQKSQFSINT
     551  LSQPESDKAE AEAVTLPPAI PIFNASSSRI FRNSYTSISS RSRRSLRLSN
     601  SRLSLSASTS RETVHDNEMP LPQLPKSPSR YSLSRRAIHA SPSTKSIHKS
     651  LSRKNIAATV AARRTLQNSA SKRSLYSLQS ISKRSLNLND LLVFDDPLPS
     701  KKPASENVNK SEPHSLESDS DFEILCDQIL FGNALDRILE EEEDNEKERD
     751  TQRQRQNDTK SSADTFTISG VSTNKENEGP EYPTKIEKNQ FNMSYKPSEN
     801  MSGLSSFPIF EKENTLSSSY LEEQKPKRAA LSDITNSFNK MNKQEGMRIE
     851  KKIQREQLQK KNDRPSPLKP IQHQELRVNS LPNDQGKPSL SLDPRRNISQ
     901  PVNSKVESLL QGLKFKKEPA SHWTHERGSL FMSEHVEDEK PVKASDVSIE
     951  SSYVPLTTVA TSSRDPSVLA ESSTIQKPML SLPSSFLNTS MTFKNLSQIL
    1001  ADDGDDKHLS VPQNQSRSVA MSHPLRKQSA KISLTPRSNL NANLSVKRNQ
    1051  GSPGSYLSND LDGISDMTFA MEIPTNTFTA QAIQLMNNDT DNNKINTSPK
    1101  ASSFTKEKVI KSAAYISKEK EPDNSDTNYI PDYTIPNTYD EKAINIFEDA
    1151  PSDEGSLNTS SSESDSRASV HRKAVSIDTM ATTNVLTPAT NVRVSLYWNN
    1201  NSSGIPRETT EEILSKLRLS PENPSNTHMQ KRFSSTRGSR DSNALGISQS
    1251  LQSMFKDLEE DQDGHTSQAD ILESSMSYSK RRPSEESVNP KQRVTMLFDE
    1301  EEEESKKVGG GKIKEEHTKL DNKISEESSQ LVLPVVEKKE NANNTENNYS
    1351  KIPKPSTIKV TKDTAMESNT QTHTKKPILK SVQNVEVEEA PSSDKKNWFV
    1401  KLFQNFSSHN NATKASKNHV TNISFDDAHM LTLNEFNKNS IDYQLKNLDH
    1451  KFGRKVVEYD CKFVKGNFKF KIKITSTPNA STVITVKKRS KHSNTSSNKA
    1501  FEKFNDDVER VIRNAGRS*

external links for Hsl1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Hsl1p
1) Thomas CL, et al.  (2003) Assembly interdependence among the S. cerevisiae bud neck ring proteins Elm1p, Hsl1p and Cdc12p. Yeast 20(9):813-26
2) McMillan JN, et al.  (1999) The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p. Mol Cell Biol 19(10):6929-39
3) Shulewitz MJ, et al.  (1999) Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 19(10):7123-37
4) Longtine MS, et al.  (2000) Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol 20(11):4049-61
5) Barral Y, et al.  (1999) Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast. Genes Dev 13(2):176-87
6) Sakchaisri K, et al.  (2004) Coupling morphogenesis to mitotic entry. Proc Natl Acad Sci U S A 101(12):4124-9
7) Ma XJ, et al.  (1996) A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev 10(11):1327-40