MDH1/YKL085W Protein Information

Standard Name	Mdh1p
Systematic Name	Ykl085wp
ORF Classification	Verified
Description	Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated (1, 2)
Name Description	Malate DeHydrogenase 1

Experimental Data
Molecules/cell	28100 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	334
Molecular Weight (Da)	35,650
Isoelectric Point (pI)	8.99

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mdh1p (InterPro)
Physical Interactions	There are 32 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012EE24 \| P17505 MIPS: YKL085W NCBI: 15826355 \| 15826356 \| 15826357 \| 15826358 \| 171892 \| 45269719 \| 486125 \| 547901 \| 6322765 \| NP_012838.1 GenBank/EMBL/DDBJ: DAA09073.1 \| AY557914 \| J02841 \| Z28085
External Classifications	EC: 1.1.1.37 [Malate dehydrogenase]

Amino Acid Sequence (or in FASTA format)
1 MLSRVAKRAF SSTVANPYKV TVLGAGGGIG QPLSLLLKLN HKVTDLRLYD 51 LKGAKGVATD LSHIPTNSVV KGFTPEEPDG LNNALKDTDM VLIPAGVPRK 101 PGMTRDDLFA INASIVRDLA AATAESAPNA AILVISNPVN STVPIVAQVL 151 KNKGVYNPKK LFGVTTLDSI RAARFISEVE NTDPTQERVN VIGGHSGITI 201 IPLISQTNHK LMSDDKRHEL IHRIQFGGDE VVKAKNGAGS ATLSMAHAGA 251 KFANAVLSGF KGERDVIEPS FVDSPLFKSE GIEFFASPVT LGPDGIEKIH 301 PIGELSSEEE EMLQKCKETL KKNIEKGVNF VASK*

Amino Acid Sequence (or in FASTA format)

       1  MLSRVAKRAF SSTVANPYKV TVLGAGGGIG QPLSLLLKLN HKVTDLRLYD
      51  LKGAKGVATD LSHIPTNSVV KGFTPEEPDG LNNALKDTDM VLIPAGVPRK
     101  PGMTRDDLFA INASIVRDLA AATAESAPNA AILVISNPVN STVPIVAQVL
     151  KNKGVYNPKK LFGVTTLDSI RAARFISEVE NTDPTQERVN VIGGHSGITI
     201  IPLISQTNHK LMSDDKRHEL IHRIQFGGDE VVKAKNGAGS ATLSMAHAGA
     251  KFANAVLSGF KGERDVIEPS FVDSPLFKSE GIEFFASPVT LGPDGIEKIH
     301  PIGELSSEEE EMLQKCKETL KKNIEKGVNF VASK*

external links for Mdh1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Mdh1p

1)	McAlister-Henn L and Thompson LM (1987) Isolation and expression of the gene encoding yeast mitochondrial malate dehydrogenase. J Bacteriol 169(11):5157-66
2)	Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41