TEF4/YKL081W Protein Information

Standard Name	Tef4p
Systematic Name	Ykl081wp
Alias	Efc1p
ORF Classification	Verified
Description	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex (1, 2)
Name Description	Translation Elongation Factor 1

Experimental Data
Molecules/cell	102000 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	412
Molecular Weight (Da)	46,520
Isoelectric Point (pI)	8.09

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tef4p (InterPro)
Physical Interactions	There are 88 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053081 \| P36008 MIPS: YKL081W NCBI: 2131112 \| 486118 \| 538258 \| 544232 \| 6322769 \| NP_012842.1 GenBank/EMBL/DDBJ: DAA09076.1 \| L01880 \| M77143 \| Z28080 \| Z28081

Amino Acid Sequence (or in FASTA format)
1 MSQGTLYINR SPRNYASEAL ISYFKLDVKI VDLEQSSEFA SLFPLKQAPA 51 FLGPKGLKLT EALAIQFYLA NQVADEKERA RLLGSDVIEK SQILRWASLA 101 NSDVMSNIAR PFLSFKGLIP YNKKDVDACF VKIDNLAAVF DARLRDYTFV 151 ATENISLGDL HAAGSWAFGL ATILGPEWRA KHPHLMRWFN TVAASPIVKT 201 PFAEVKLAEK ALTYTPPKKQ KAEKPKAEKS KAEKKKDEAK PADDAAPAKK 251 PKHPLEALGK STFVLDDWKR KYSNDDTRPV ALPWFWEHYN PEEYSIWKVG 301 YKYNDELTLT FMSNNLVGGF FNRLSASTKY MFGCLVVYGE NNNNGIVGAV 351 MVRGQDFAPA FDVAPDWESY EYTKLDPTKE EDKEFVNNMW AWDKPVVVNG 401 EDKEIVDGKV LK*

Amino Acid Sequence (or in FASTA format)

       1  MSQGTLYINR SPRNYASEAL ISYFKLDVKI VDLEQSSEFA SLFPLKQAPA
      51  FLGPKGLKLT EALAIQFYLA NQVADEKERA RLLGSDVIEK SQILRWASLA
     101  NSDVMSNIAR PFLSFKGLIP YNKKDVDACF VKIDNLAAVF DARLRDYTFV
     151  ATENISLGDL HAAGSWAFGL ATILGPEWRA KHPHLMRWFN TVAASPIVKT
     201  PFAEVKLAEK ALTYTPPKKQ KAEKPKAEKS KAEKKKDEAK PADDAAPAKK
     251  PKHPLEALGK STFVLDDWKR KYSNDDTRPV ALPWFWEHYN PEEYSIWKVG
     301  YKYNDELTLT FMSNNLVGGF FNRLSASTKY MFGCLVVYGE NNNNGIVGAV
     351  MVRGQDFAPA FDVAPDWESY EYTKLDPTKE EDKEFVNNMW AWDKPVVVNG
     401  EDKEIVDGKV LK*

external links for Tef4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Tef4p

1)	Kinzy TG, et al. (1994) Multiple genes encode the translation elongation factor EF-1 gamma in Saccharomyces cerevisiae. Nucleic Acids Res 22(13):2703-7
2)	Jeppesen MG, et al. (2003) The crystal structure of the glutathione S-transferase-like domain of elongation factor 1Bgamma from Saccharomyces cerevisiae. J Biol Chem 278(47):47190-8
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41