DHR2/YKL078W Protein Information

Standard Name	Dhr2p
Systematic Name	Ykl078wp
ORF Classification	Verified
Description	Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis (1)
Name Description	DEAH-box RNA helicase 1

Experimental Data
Molecules/cell	721 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	735
Molecular Weight (Da)	82,713
Isoelectric Point (pI)	9.43

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Dhr2p (InterPro)
Physical Interactions	There are 18 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000129370 \| P36009 MIPS: YKL078W NCBI: 2218148 \| 414604 \| 414716 \| 486112 \| 549698 \| 6322772 \| NP_012845.1 GenBank/EMBL/DDBJ: DAA09079.1 \| AF005090 \| L15328 \| X75560 \| Z28078
External Classifications	EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]

Amino Acid Sequence (or in FASTA format)
1 MAANSNSRVA SNHTSKKQKV RRNIHPFTNN TRIKRASKIV KFNDSGEGDH 51 VSDQRSNKEN VLTYKSLKSR ASDLLKMRET LPVYQHKREI MSYIESNPVT 101 VLIGETGSGK STQIPQFVLE KLYDTKKHGS IAVTQPRRVA AINLATRVAQ 151 EHGCKLGEQV GYSVRFDNTT TTRTRLKYLT DGMLLRELMM NSDLREYSVI 201 VIDEAHERTV LTDLILGFLK SLIQGPRPDL RIIVMSATLQ AEKFSEFFNN 251 APILFVEGRK FDVKQYYLKA PTDDIVDAVI RCCIQINQGE ELGDILCFLP 301 GQEEIDKAVT IMEKIAKYVS DEAPVPLIVP YPLYAALPAV QQSLVFAPIK 351 GFKRKVVFST NIAETSVTIS GVKFVVDSGL RKVKVWRHQL GLATLLTVPI 401 SQASAMQRSG RAGRESEGKS FRLYCESDYV KLPKQSEPEI ARSDVTSPVL 451 MLKRYGVDDL LNWTWFENPG KEAIVMGLQE LYELGALDTR GKITKRGQQM 501 ALLPLQPHLS SVLIKASEVG CLSQVIDIVS CLSVENLLLN PSPEERDEVN 551 ERRLSLCNAG KRYGDLIMLK ELFDIYFYEL GKSQDASSER NDWCKGLCIS 601 IRGFKNVIRV RDQLRVYCKR LFSSISEEDE ESKKIGEDGE LISKILKCFL 651 TGFIKNTAIG MPDRSYRTVS TGEPISIHPS SMLFMNKSCP GIMYTEYVFT 701 TKGYARNVSR IELSWLQEVV TNAAAVAKQK VSDSK*

Amino Acid Sequence (or in FASTA format)

       1  MAANSNSRVA SNHTSKKQKV RRNIHPFTNN TRIKRASKIV KFNDSGEGDH
      51  VSDQRSNKEN VLTYKSLKSR ASDLLKMRET LPVYQHKREI MSYIESNPVT
     101  VLIGETGSGK STQIPQFVLE KLYDTKKHGS IAVTQPRRVA AINLATRVAQ
     151  EHGCKLGEQV GYSVRFDNTT TTRTRLKYLT DGMLLRELMM NSDLREYSVI
     201  VIDEAHERTV LTDLILGFLK SLIQGPRPDL RIIVMSATLQ AEKFSEFFNN
     251  APILFVEGRK FDVKQYYLKA PTDDIVDAVI RCCIQINQGE ELGDILCFLP
     301  GQEEIDKAVT IMEKIAKYVS DEAPVPLIVP YPLYAALPAV QQSLVFAPIK
     351  GFKRKVVFST NIAETSVTIS GVKFVVDSGL RKVKVWRHQL GLATLLTVPI
     401  SQASAMQRSG RAGRESEGKS FRLYCESDYV KLPKQSEPEI ARSDVTSPVL
     451  MLKRYGVDDL LNWTWFENPG KEAIVMGLQE LYELGALDTR GKITKRGQQM
     501  ALLPLQPHLS SVLIKASEVG CLSQVIDIVS CLSVENLLLN PSPEERDEVN
     551  ERRLSLCNAG KRYGDLIMLK ELFDIYFYEL GKSQDASSER NDWCKGLCIS
     601  IRGFKNVIRV RDQLRVYCKR LFSSISEEDE ESKKIGEDGE LISKILKCFL
     651  TGFIKNTAIG MPDRSYRTVS TGEPISIHPS SMLFMNKSCP GIMYTEYVFT
     701  TKGYARNVSR IELSWLQEVV TNAAAVAKQK VSDSK*

external links for Dhr2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Dhr2p

1)	Colley A, et al. (2000) Dhr1p, a putative DEAH-box RNA helicase, is associated with the box C+D snoRNP U3. Mol Cell Biol 20(19):7238-46
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41